Complex analysis of association of inflammation gene polymorphisms with myocardial infarction

M. A. Sudomoina; T. S. Sukhinina; R. M. Barsova; A. V. Favorov; R. M. Sakhnovich; B. V. Titov; N. A. Matveeva; I. N. Rybalkin; T. N. Vlasik; M. F. Ochs; M. Ya Ruda; O. O. Favorova

doi:10.1134/S0026893310030088

Complex analysis of association of inflammation gene polymorphisms with myocardial infarction

M. A. Sudomoina, T. S. Sukhinina, R. M. Barsova, A. V. Favorov, R. M. Sakhnovich, B. V. Titov, N. A. Matveeva, I. N. Rybalkin, T. N. Vlasik, M. F. Ochs, M. Ya Ruda, O. O. Favorova

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5 Scopus citations

Abstract

Frequencies of the carriership of alleles and genotypes of functionally important polymorphous loci of some inflammation genes (proinflammatory cytokine genes IL-6, LTA, and TNF; anti-inflammatory cytokine gene TGFB1; and CC chemokine receptor 5 gene CCR5) were analyzed in 199 ethnic Russian patients with myocardial infarction (MI) and in a control group of 142 persons of the same ethnic descent. Complex analysis by the APSampler algorithm revealed associations of MI with the carriership of all polymorphic variants either regarded as individual risk factors (insertion-deletion polymorphism of CCR5 and SNP G252A LTA) or in combination with other alleles or genotypes. The carriership of bi-or triallelic combinations was associated with MI more reliable than the carriership of any subsets: single alleles or allele pairs. The protective triallelic combination d*CCR5 + 252G*LTA + -174C*Il-6 was found to be the most significant (p = 0.0006, OR = 0.23, CI = 0.090-0.56). Separate analysis of genetic susceptibility to MI in men and women demonstrated sexual dimorphism for the CCR5 gene.

Original language	English (US)
Pages (from-to)	407-414
Number of pages	8
Journal	Molecular Biology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1134/S0026893310030088
State	Published - 2010
Externally published	Yes

Keywords

APSampler
Allelic polymorphism
Cytokines
DNA
Genes
Human
Inflammation
Myocardial infarction
Polymerase chain reaction
Russians

ASJC Scopus subject areas

Biophysics
Structural Biology

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10.1134/S0026893310030088

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Sudomoina, M. A., Sukhinina, T. S., Barsova, R. M., Favorov, A. V., Sakhnovich, R. M., Titov, B. V., Matveeva, N. A., Rybalkin, I. N., Vlasik, T. N., Ochs, M. F., Ruda, M. Y., & Favorova, O. O. (2010). Complex analysis of association of inflammation gene polymorphisms with myocardial infarction. Molecular Biology, 44(3), 407-414. https://doi.org/10.1134/S0026893310030088

@article{a03fbe2206a34740991765a07ec7ea32,

title = "Complex analysis of association of inflammation gene polymorphisms with myocardial infarction",

abstract = "Frequencies of the carriership of alleles and genotypes of functionally important polymorphous loci of some inflammation genes (proinflammatory cytokine genes IL-6, LTA, and TNF; anti-inflammatory cytokine gene TGFB1; and CC chemokine receptor 5 gene CCR5) were analyzed in 199 ethnic Russian patients with myocardial infarction (MI) and in a control group of 142 persons of the same ethnic descent. Complex analysis by the APSampler algorithm revealed associations of MI with the carriership of all polymorphic variants either regarded as individual risk factors (insertion-deletion polymorphism of CCR5 and SNP G252A LTA) or in combination with other alleles or genotypes. The carriership of bi-or triallelic combinations was associated with MI more reliable than the carriership of any subsets: single alleles or allele pairs. The protective triallelic combination d*CCR5 + 252G*LTA + -174C*Il-6 was found to be the most significant (p = 0.0006, OR = 0.23, CI = 0.090-0.56). Separate analysis of genetic susceptibility to MI in men and women demonstrated sexual dimorphism for the CCR5 gene.",

keywords = "APSampler, Allelic polymorphism, Cytokines, DNA, Genes, Human, Inflammation, Myocardial infarction, Polymerase chain reaction, Russians",

author = "Sudomoina, {M. A.} and Sukhinina, {T. S.} and Barsova, {R. M.} and Favorov, {A. V.} and Sakhnovich, {R. M.} and Titov, {B. V.} and Matveeva, {N. A.} and Rybalkin, {I. N.} and Vlasik, {T. N.} and Ochs, {M. F.} and Ruda, {M. Ya} and Favorova, {O. O.}",

note = "Funding Information: ACKNOWLEDGMENTS This work was supported by the Russian Founda tion for Basic Research, project no. 07 04 01715a and State Contract 8/3 409n 09, New Methods for Athe rosclerosis Prevention, Diagnosis, and Treatment.",

year = "2010",

doi = "10.1134/S0026893310030088",

language = "English (US)",

volume = "44",

pages = "407--414",

journal = "Molecular Biology",

issn = "0026-8933",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "3",

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TY - JOUR

T1 - Complex analysis of association of inflammation gene polymorphisms with myocardial infarction

AU - Sudomoina, M. A.

AU - Sukhinina, T. S.

AU - Barsova, R. M.

AU - Favorov, A. V.

AU - Sakhnovich, R. M.

AU - Titov, B. V.

AU - Matveeva, N. A.

AU - Rybalkin, I. N.

AU - Vlasik, T. N.

AU - Ochs, M. F.

AU - Ruda, M. Ya

AU - Favorova, O. O.

N1 - Funding Information: ACKNOWLEDGMENTS This work was supported by the Russian Founda tion for Basic Research, project no. 07 04 01715a and State Contract 8/3 409n 09, New Methods for Athe rosclerosis Prevention, Diagnosis, and Treatment.

PY - 2010

Y1 - 2010

N2 - Frequencies of the carriership of alleles and genotypes of functionally important polymorphous loci of some inflammation genes (proinflammatory cytokine genes IL-6, LTA, and TNF; anti-inflammatory cytokine gene TGFB1; and CC chemokine receptor 5 gene CCR5) were analyzed in 199 ethnic Russian patients with myocardial infarction (MI) and in a control group of 142 persons of the same ethnic descent. Complex analysis by the APSampler algorithm revealed associations of MI with the carriership of all polymorphic variants either regarded as individual risk factors (insertion-deletion polymorphism of CCR5 and SNP G252A LTA) or in combination with other alleles or genotypes. The carriership of bi-or triallelic combinations was associated with MI more reliable than the carriership of any subsets: single alleles or allele pairs. The protective triallelic combination d*CCR5 + 252G*LTA + -174C*Il-6 was found to be the most significant (p = 0.0006, OR = 0.23, CI = 0.090-0.56). Separate analysis of genetic susceptibility to MI in men and women demonstrated sexual dimorphism for the CCR5 gene.

AB - Frequencies of the carriership of alleles and genotypes of functionally important polymorphous loci of some inflammation genes (proinflammatory cytokine genes IL-6, LTA, and TNF; anti-inflammatory cytokine gene TGFB1; and CC chemokine receptor 5 gene CCR5) were analyzed in 199 ethnic Russian patients with myocardial infarction (MI) and in a control group of 142 persons of the same ethnic descent. Complex analysis by the APSampler algorithm revealed associations of MI with the carriership of all polymorphic variants either regarded as individual risk factors (insertion-deletion polymorphism of CCR5 and SNP G252A LTA) or in combination with other alleles or genotypes. The carriership of bi-or triallelic combinations was associated with MI more reliable than the carriership of any subsets: single alleles or allele pairs. The protective triallelic combination d*CCR5 + 252G*LTA + -174C*Il-6 was found to be the most significant (p = 0.0006, OR = 0.23, CI = 0.090-0.56). Separate analysis of genetic susceptibility to MI in men and women demonstrated sexual dimorphism for the CCR5 gene.

KW - APSampler

KW - Allelic polymorphism

KW - Cytokines

KW - DNA

KW - Genes

KW - Human

KW - Inflammation

KW - Myocardial infarction

KW - Polymerase chain reaction

KW - Russians

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U2 - 10.1134/S0026893310030088

DO - 10.1134/S0026893310030088

M3 - Article

AN - SCOPUS:77954151257

SN - 0026-8933

VL - 44

SP - 407

EP - 414

JO - Molecular Biology

JF - Molecular Biology

IS - 3

ER -

Complex analysis of association of inflammation gene polymorphisms with myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

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