TY - JOUR
T1 - Complete Transposition of Great Vessels
T2 - Manifestation in Two Siblings Confirmed at Autopsy
AU - Lynch, H. T.
AU - Grissom, R. L.
AU - Mooring, P.
AU - Krush, A.
PY - 1964/12/14
Y1 - 1964/12/14
N2 - A family has been studied wherein two siblings manifested complete transposition of the great vessels, confirmed at autopsy. Consanguinity was absent and no toxic exposure was found during the prenatal period in either case. All available family members were studied and found to be normal. Only one previous report of this cardiac anomaly in siblings has been found; however, there have been several reports showing complete transposition of the great vessels in one sibling, while another sibling manifested cardiac defects within the spectrum of truncoconal malformations. A genetic fault is postulated as the etiology of some truncoconal malformations, in which a gene effect during embryogenesis, in concert with the intrauterine milieu, produces various anomalies.
AB - A family has been studied wherein two siblings manifested complete transposition of the great vessels, confirmed at autopsy. Consanguinity was absent and no toxic exposure was found during the prenatal period in either case. All available family members were studied and found to be normal. Only one previous report of this cardiac anomaly in siblings has been found; however, there have been several reports showing complete transposition of the great vessels in one sibling, while another sibling manifested cardiac defects within the spectrum of truncoconal malformations. A genetic fault is postulated as the etiology of some truncoconal malformations, in which a gene effect during embryogenesis, in concert with the intrauterine milieu, produces various anomalies.
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U2 - 10.1001/jama.1964.03070240015003
DO - 10.1001/jama.1964.03070240015003
M3 - Article
C2 - 14214519
AN - SCOPUS:76549152033
SN - 0098-7484
VL - 190
SP - 969
EP - 972
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 11
ER -