Complete spotaneous regression of pulmonary metastatic melanoma

Timothy S Wang, Lori Lowe, John W. Smith, Isaac R. Francis, Vernon K. Sondak, Lynn Dworzanian, Steven Finkelstein, Craig L. Slingluff, Timothy M. Johnson

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Complete spontaneous regression of melanoma metastatic to the lungs is a rare event. OBJECTIVE. To report a case of biopsy-proven melanoma metastic to the lung with complete spontaneous regression. METHODS. Multidisciplinary case report. RESULTS. A 35-year-old white female was diagnosed with metastic melanoma to the lung. A pleural biopsy confirmed the diagnosis. Partial spontaneous regression was noted by a staging computed tomography scan prior to enrollment in an investigational protocol. Complete spontaneous regression occured over 5 months withtout any form of conventional or alternative therapy, and the patient remains disease-free 3 years diagnosis. CONCLUSIONS. Our case represents the seventh case of complete spontaneous regression of melanoma metastatic to the lung, and the only case with histologic confirmation of both the primary and pulmonary metastatic lesions. The patient was pregnant twice between the time of her initial diagnosis of primary melanoma and pulmonary metastatic disease.

Original languageEnglish (US)
Pages (from-to)915-919
Number of pages5
JournalDermatologic Surgery
Volume24
Issue number8
StatePublished - Aug 1998
Externally publishedYes

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Melanoma
Lung
Biopsy
Complementary Therapies
Lung Diseases
Tomography

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Wang, T. S., Lowe, L., Smith, J. W., Francis, I. R., Sondak, V. K., Dworzanian, L., ... Johnson, T. M. (1998). Complete spotaneous regression of pulmonary metastatic melanoma. Dermatologic Surgery, 24(8), 915-919.

Complete spotaneous regression of pulmonary metastatic melanoma. / Wang, Timothy S; Lowe, Lori; Smith, John W.; Francis, Isaac R.; Sondak, Vernon K.; Dworzanian, Lynn; Finkelstein, Steven; Slingluff, Craig L.; Johnson, Timothy M.

In: Dermatologic Surgery, Vol. 24, No. 8, 08.1998, p. 915-919.

Research output: Contribution to journalArticle

Wang, TS, Lowe, L, Smith, JW, Francis, IR, Sondak, VK, Dworzanian, L, Finkelstein, S, Slingluff, CL & Johnson, TM 1998, 'Complete spotaneous regression of pulmonary metastatic melanoma', Dermatologic Surgery, vol. 24, no. 8, pp. 915-919.
Wang TS, Lowe L, Smith JW, Francis IR, Sondak VK, Dworzanian L et al. Complete spotaneous regression of pulmonary metastatic melanoma. Dermatologic Surgery. 1998 Aug;24(8):915-919.
Wang, Timothy S ; Lowe, Lori ; Smith, John W. ; Francis, Isaac R. ; Sondak, Vernon K. ; Dworzanian, Lynn ; Finkelstein, Steven ; Slingluff, Craig L. ; Johnson, Timothy M. / Complete spotaneous regression of pulmonary metastatic melanoma. In: Dermatologic Surgery. 1998 ; Vol. 24, No. 8. pp. 915-919.
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AB - BACKGROUND. Complete spontaneous regression of melanoma metastatic to the lungs is a rare event. OBJECTIVE. To report a case of biopsy-proven melanoma metastic to the lung with complete spontaneous regression. METHODS. Multidisciplinary case report. RESULTS. A 35-year-old white female was diagnosed with metastic melanoma to the lung. A pleural biopsy confirmed the diagnosis. Partial spontaneous regression was noted by a staging computed tomography scan prior to enrollment in an investigational protocol. Complete spontaneous regression occured over 5 months withtout any form of conventional or alternative therapy, and the patient remains disease-free 3 years diagnosis. CONCLUSIONS. Our case represents the seventh case of complete spontaneous regression of melanoma metastatic to the lung, and the only case with histologic confirmation of both the primary and pulmonary metastatic lesions. The patient was pregnant twice between the time of her initial diagnosis of primary melanoma and pulmonary metastatic disease.

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