Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets

Michelle Ojemuyiwa; Karen Zeman; Alexander Spira; Bryan Oronsky; Carolyn Ray; Jane B. Trepel; Min Jung Lee; Ifeyinwa Onyiuke; Christina Brzezniak

doi:10.1002/ccr3.1880

Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets

Michelle Ojemuyiwa, Karen Zeman, Alexander Spira, Bryan Oronsky, Carolyn Ray, Jane B. Trepel, Min Jung Lee, Ifeyinwa Onyiuke, Christina Brzezniak

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Presented herein is the case of a heavily pretreated patient with high-grade neuroendocrine prostate cancer that achieved a complete metabolic response on platinum-based chemotherapy after treatment with the dual CD-47 and SIRP-α inhibitor, RRx-001, in a Phase II clinical trial.

Original language	English (US)
Pages (from-to)	2478-2481
Number of pages	4
Journal	Clinical Case Reports
Volume	6
Issue number	12
DOIs	https://doi.org/10.1002/ccr3.1880
State	Published - Dec 2018

Keywords

RRx-001
macrophage repolarization
neuroendocrine cancer
platinum doublets
priming
prostate cancer

ASJC Scopus subject areas

General Medicine

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10.1002/ccr3.1880

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title = "Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets",

abstract = "Presented herein is the case of a heavily pretreated patient with high-grade neuroendocrine prostate cancer that achieved a complete metabolic response on platinum-based chemotherapy after treatment with the dual CD-47 and SIRP-α inhibitor, RRx-001, in a Phase II clinical trial.",

keywords = "RRx-001, macrophage repolarization, neuroendocrine cancer, platinum doublets, priming, prostate cancer",

author = "Michelle Ojemuyiwa and Karen Zeman and Alexander Spira and Bryan Oronsky and Carolyn Ray and Trepel, {Jane B.} and Lee, {Min Jung} and Ifeyinwa Onyiuke and Christina Brzezniak",

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year = "2018",

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doi = "10.1002/ccr3.1880",

language = "English (US)",

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AU - Ojemuyiwa, Michelle

AU - Zeman, Karen

AU - Spira, Alexander

AU - Oronsky, Bryan

AU - Ray, Carolyn

AU - Trepel, Jane B.

AU - Lee, Min Jung

AU - Onyiuke, Ifeyinwa

AU - Brzezniak, Christina

PY - 2018/12

Y1 - 2018/12

N2 - Presented herein is the case of a heavily pretreated patient with high-grade neuroendocrine prostate cancer that achieved a complete metabolic response on platinum-based chemotherapy after treatment with the dual CD-47 and SIRP-α inhibitor, RRx-001, in a Phase II clinical trial.

AB - Presented herein is the case of a heavily pretreated patient with high-grade neuroendocrine prostate cancer that achieved a complete metabolic response on platinum-based chemotherapy after treatment with the dual CD-47 and SIRP-α inhibitor, RRx-001, in a Phase II clinical trial.

KW - RRx-001

KW - macrophage repolarization

KW - neuroendocrine cancer

KW - platinum doublets

KW - priming

KW - prostate cancer

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ER -

Complete metabolic response of metastatic castration-resistant neuroendocrine carcinoma of the prostate after treatment with RRx-001 and reintroduced platinum doublets

Abstract

Keywords

ASJC Scopus subject areas

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