Complete global myocardial ischemia in dogs

R. B. Jennings, K. A. Reimer, Charles Jr Steenbergen

Research output: Contribution to journalArticle

Abstract

Complete global myocardial ischemia or zero coronary arterial flow in dogs results in a series of well-defined changes which begin when the myocardium converts from aerobic to anaerobic metabolism. These processes continue until the myocardium dies. The products of anaerobic metabolism, chiefly glycolytic intermediates, inorganic phosphate, H+, and creatine, are prodcued intracellularly and accumulate in the tissue. Because the demand for high-energy phosphates (HEP) in the tissue exceeds the supply available from anaerobic glycolysis and HEP reserves, net ATP level declines, approaching zero after 100 min of ischemia at 37°C. At this time, the changes in totally ischemic tissue in vitro are equivalent to those seen in myocytes irreversibly injured by severe ischemia in vivo. During reoxygenation after total ischemia, the resumption of effective contractile activity depends partly on the metabolic changes and degree of myocyte injury sustained during ischemia.

Original languageEnglish (US)
Pages (from-to)988-996
Number of pages9
JournalCritical Care Medicine
Volume16
Issue number10
StatePublished - 1988
Externally publishedYes

Fingerprint

Myocardial Ischemia
Ischemia
Dogs
Anaerobiosis
Phosphates
Muscle Cells
Myocardium
Creatine
Glycolysis
Adenosine Triphosphate
Wounds and Injuries

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Jennings, R. B., Reimer, K. A., & Steenbergen, C. J. (1988). Complete global myocardial ischemia in dogs. Critical Care Medicine, 16(10), 988-996.

Complete global myocardial ischemia in dogs. / Jennings, R. B.; Reimer, K. A.; Steenbergen, Charles Jr.

In: Critical Care Medicine, Vol. 16, No. 10, 1988, p. 988-996.

Research output: Contribution to journalArticle

Jennings, RB, Reimer, KA & Steenbergen, CJ 1988, 'Complete global myocardial ischemia in dogs', Critical Care Medicine, vol. 16, no. 10, pp. 988-996.
Jennings, R. B. ; Reimer, K. A. ; Steenbergen, Charles Jr. / Complete global myocardial ischemia in dogs. In: Critical Care Medicine. 1988 ; Vol. 16, No. 10. pp. 988-996.
@article{b6a33dca71ac46bb9f2d2475c7b41e24,
title = "Complete global myocardial ischemia in dogs",
abstract = "Complete global myocardial ischemia or zero coronary arterial flow in dogs results in a series of well-defined changes which begin when the myocardium converts from aerobic to anaerobic metabolism. These processes continue until the myocardium dies. The products of anaerobic metabolism, chiefly glycolytic intermediates, inorganic phosphate, H+, and creatine, are prodcued intracellularly and accumulate in the tissue. Because the demand for high-energy phosphates (HEP) in the tissue exceeds the supply available from anaerobic glycolysis and HEP reserves, net ATP level declines, approaching zero after 100 min of ischemia at 37°C. At this time, the changes in totally ischemic tissue in vitro are equivalent to those seen in myocytes irreversibly injured by severe ischemia in vivo. During reoxygenation after total ischemia, the resumption of effective contractile activity depends partly on the metabolic changes and degree of myocyte injury sustained during ischemia.",
author = "Jennings, {R. B.} and Reimer, {K. A.} and Steenbergen, {Charles Jr}",
year = "1988",
language = "English (US)",
volume = "16",
pages = "988--996",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Complete global myocardial ischemia in dogs

AU - Jennings, R. B.

AU - Reimer, K. A.

AU - Steenbergen, Charles Jr

PY - 1988

Y1 - 1988

N2 - Complete global myocardial ischemia or zero coronary arterial flow in dogs results in a series of well-defined changes which begin when the myocardium converts from aerobic to anaerobic metabolism. These processes continue until the myocardium dies. The products of anaerobic metabolism, chiefly glycolytic intermediates, inorganic phosphate, H+, and creatine, are prodcued intracellularly and accumulate in the tissue. Because the demand for high-energy phosphates (HEP) in the tissue exceeds the supply available from anaerobic glycolysis and HEP reserves, net ATP level declines, approaching zero after 100 min of ischemia at 37°C. At this time, the changes in totally ischemic tissue in vitro are equivalent to those seen in myocytes irreversibly injured by severe ischemia in vivo. During reoxygenation after total ischemia, the resumption of effective contractile activity depends partly on the metabolic changes and degree of myocyte injury sustained during ischemia.

AB - Complete global myocardial ischemia or zero coronary arterial flow in dogs results in a series of well-defined changes which begin when the myocardium converts from aerobic to anaerobic metabolism. These processes continue until the myocardium dies. The products of anaerobic metabolism, chiefly glycolytic intermediates, inorganic phosphate, H+, and creatine, are prodcued intracellularly and accumulate in the tissue. Because the demand for high-energy phosphates (HEP) in the tissue exceeds the supply available from anaerobic glycolysis and HEP reserves, net ATP level declines, approaching zero after 100 min of ischemia at 37°C. At this time, the changes in totally ischemic tissue in vitro are equivalent to those seen in myocytes irreversibly injured by severe ischemia in vivo. During reoxygenation after total ischemia, the resumption of effective contractile activity depends partly on the metabolic changes and degree of myocyte injury sustained during ischemia.

UR - http://www.scopus.com/inward/record.url?scp=0023687357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023687357&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 988

EP - 996

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 10

ER -