Complete genome sequence of Treponema pallidum, the syphilis spirochete

Claire M. Fraser; Steven J. Norris; George M. Weinstock; Owen White; Granger G. Sutton; Robert Dodson; Michelle Gwinn; Erin K. Hickey; Rebecca Clayton; Karen A. Ketchum; Erica Sodergren; John M. Hardham; Michael P. McLeod; Steven Salzberg; Jeremy Peterson; Hanif Khalak; Delwood Richardson; Jerrilyn K. Howell; Monjula Chidambaram; Teresa Utterback; Lisa McDonald; Patricia Artiach; Cheryl Bowman; Matthew D. Cotton; Claire Fujii; Stacey Garland; Bonnie Hatch; Kurt Horst; Kevin Roberts; Mina Sandusky; Janice Weidman; Hamilton O. Smith; J. Craig Venter

doi:10.1126/science.281.5375.375

Complete genome sequence of Treponema pallidum, the syphilis spirochete

Claire M. Fraser, Steven J. Norris, George M. Weinstock, Owen White, Granger G. Sutton, Robert Dodson, Michelle Gwinn, Erin K. Hickey, Rebecca Clayton, Karen A. Ketchum, Erica Sodergren, John M. Hardham, Michael P. McLeod, Steven Salzberg, Jeremy Peterson, Hanif Khalak, Delwood Richardson, Jerrilyn K. Howell, Monjula Chidambaram, Teresa UtterbackLisa McDonald, Patricia Artiach, Cheryl Bowman, Matthew D. Cotton, Claire Fujii, Stacey Garland, Bonnie Hatch, Kurt Horst, Kevin Roberts, Mina Sandusky, Janice Weidman, Hamilton O. Smith, J. Craig Venter

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Abstract

The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phosphoenolpyruvate: phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.

Original language	English (US)
Pages (from-to)	375-388
Number of pages	14
Journal	Science
Volume	281
Issue number	5375
DOIs	https://doi.org/10.1126/science.281.5375.375
State	Published - Jul 17 1998
Externally published	Yes

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Fraser, C. M., Norris, S. J., Weinstock, G. M., White, O., Sutton, G. G., Dodson, R., Gwinn, M., Hickey, E. K., Clayton, R., Ketchum, K. A., Sodergren, E., Hardham, J. M., McLeod, M. P., Salzberg, S., Peterson, J., Khalak, H., Richardson, D., Howell, J. K., Chidambaram, M., ... Venter, J. C. (1998). Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science, 281(5375), 375-388. https://doi.org/10.1126/science.281.5375.375

Fraser, CM, Norris, SJ, Weinstock, GM, White, O, Sutton, GG, Dodson, R, Gwinn, M, Hickey, EK, Clayton, R, Ketchum, KA, Sodergren, E, Hardham, JM, McLeod, MP, Salzberg, S, Peterson, J, Khalak, H, Richardson, D, Howell, JK, Chidambaram, M, Utterback, T, McDonald, L, Artiach, P, Bowman, C, Cotton, MD, Fujii, C, Garland, S, Hatch, B, Horst, K, Roberts, K, Sandusky, M, Weidman, J, Smith, HO & Venter, JC 1998, 'Complete genome sequence of Treponema pallidum, the syphilis spirochete', Science, vol. 281, no. 5375, pp. 375-388. https://doi.org/10.1126/science.281.5375.375

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title = "Complete genome sequence of Treponema pallidum, the syphilis spirochete",

abstract = "The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phosphoenolpyruvate: phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.",

author = "Fraser, {Claire M.} and Norris, {Steven J.} and Weinstock, {George M.} and Owen White and Sutton, {Granger G.} and Robert Dodson and Michelle Gwinn and Hickey, {Erin K.} and Rebecca Clayton and Ketchum, {Karen A.} and Erica Sodergren and Hardham, {John M.} and McLeod, {Michael P.} and Steven Salzberg and Jeremy Peterson and Hanif Khalak and Delwood Richardson and Howell, {Jerrilyn K.} and Monjula Chidambaram and Teresa Utterback and Lisa McDonald and Patricia Artiach and Cheryl Bowman and Cotton, {Matthew D.} and Claire Fujii and Stacey Garland and Bonnie Hatch and Kurt Horst and Kevin Roberts and Mina Sandusky and Janice Weidman and Smith, {Hamilton O.} and Venter, {J. Craig}",

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doi = "10.1126/science.281.5375.375",

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AU - Sutton, Granger G.

AU - Dodson, Robert

AU - Gwinn, Michelle

AU - Hickey, Erin K.

AU - Clayton, Rebecca

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AU - Sodergren, Erica

AU - Hardham, John M.

AU - McLeod, Michael P.

AU - Salzberg, Steven

AU - Peterson, Jeremy

AU - Khalak, Hanif

AU - Richardson, Delwood

AU - Howell, Jerrilyn K.

AU - Chidambaram, Monjula

AU - Utterback, Teresa

AU - McDonald, Lisa

AU - Artiach, Patricia

AU - Bowman, Cheryl

AU - Cotton, Matthew D.

AU - Fujii, Claire

AU - Garland, Stacey

AU - Hatch, Bonnie

AU - Horst, Kurt

AU - Roberts, Kevin

AU - Sandusky, Mina

AU - Weidman, Janice

AU - Smith, Hamilton O.

AU - Venter, J. Craig

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Complete genome sequence of Treponema pallidum, the syphilis spirochete

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