TY - JOUR
T1 - Complete and incomplete Kawasaki disease
T2 - Two sides of the same coin
AU - Manlhiot, Cedric
AU - Christie, Erin
AU - McCrindle, Brian W.
AU - Rosenberg, Hans
AU - Chahal, Nita
AU - Yeung, Rae S.M.
N1 - Funding Information:
Acknowledgments This study was supported in part by the Arthritis Society Investigator Award (RSMY) and the CIBC World Markets Children's Miracle Foundation (BWM).
PY - 2012/4
Y1 - 2012/4
N2 - We sought to determine differences in clinical presentation, treatment response and coronary artery outcomes between complete and incomplete KD. All patients treated for KD between January 1990 and April 2007 were reviewed. Patients were classified as having an incomplete presentation if presenting with fever ≥5 days and <4 "classictm KD clinical signs. A total of 955 patients were included. Incomplete clinical presentation was seen in 217 cases (23%). Patient's demographic, clinical and laboratory characteristics were similar between groups with few exceptions. Patients presenting with incomplete KD had a longer median interval from symptom onset to diagnosis (7 [4-17] versus 6 [6-13] days, p<0.001) and were less likely to be treated with intravenous immunoglobulin (86% versus 96%, p<0.001). No significant difference between groups were seen in regard to coronary artery abnormalities (incomplete 13%versus complete 11%, p=0.58). Conclusion: Complete and incomplete KD appear to be different sides of the same coin, differing only in the number of signs and symptoms at presentation. Similar laboratory findings and coronary artery outcomes between the two groups support this conclusion.
AB - We sought to determine differences in clinical presentation, treatment response and coronary artery outcomes between complete and incomplete KD. All patients treated for KD between January 1990 and April 2007 were reviewed. Patients were classified as having an incomplete presentation if presenting with fever ≥5 days and <4 "classictm KD clinical signs. A total of 955 patients were included. Incomplete clinical presentation was seen in 217 cases (23%). Patient's demographic, clinical and laboratory characteristics were similar between groups with few exceptions. Patients presenting with incomplete KD had a longer median interval from symptom onset to diagnosis (7 [4-17] versus 6 [6-13] days, p<0.001) and were less likely to be treated with intravenous immunoglobulin (86% versus 96%, p<0.001). No significant difference between groups were seen in regard to coronary artery abnormalities (incomplete 13%versus complete 11%, p=0.58). Conclusion: Complete and incomplete KD appear to be different sides of the same coin, differing only in the number of signs and symptoms at presentation. Similar laboratory findings and coronary artery outcomes between the two groups support this conclusion.
KW - Clinical signs
KW - Coronary artery abnormalities
KW - Kawasaki disease
UR - http://www.scopus.com/inward/record.url?scp=84860309090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860309090&partnerID=8YFLogxK
U2 - 10.1007/s00431-011-1631-2
DO - 10.1007/s00431-011-1631-2
M3 - Article
C2 - 22134803
AN - SCOPUS:84860309090
SN - 0340-6199
VL - 171
SP - 657
EP - 662
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 4
ER -