Complete and incomplete Kawasaki disease: Two sides of the same coin

Cedric Manlhiot, Erin Christie, Brian W. McCrindle, Hans Rosenberg, Nita Chahal, Rae S.M. Yeung

Research output: Contribution to journalArticle

Abstract

We sought to determine differences in clinical presentation, treatment response and coronary artery outcomes between complete and incomplete KD. All patients treated for KD between January 1990 and April 2007 were reviewed. Patients were classified as having an incomplete presentation if presenting with fever ≥5 days and <4 "classictm KD clinical signs. A total of 955 patients were included. Incomplete clinical presentation was seen in 217 cases (23%). Patient's demographic, clinical and laboratory characteristics were similar between groups with few exceptions. Patients presenting with incomplete KD had a longer median interval from symptom onset to diagnosis (7 [4-17] versus 6 [6-13] days, p<0.001) and were less likely to be treated with intravenous immunoglobulin (86% versus 96%, p<0.001). No significant difference between groups were seen in regard to coronary artery abnormalities (incomplete 13%versus complete 11%, p=0.58). Conclusion: Complete and incomplete KD appear to be different sides of the same coin, differing only in the number of signs and symptoms at presentation. Similar laboratory findings and coronary artery outcomes between the two groups support this conclusion.

Original languageEnglish (US)
Pages (from-to)657-662
Number of pages6
JournalEuropean Journal of Pediatrics
Volume171
Issue number4
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Keywords

  • Clinical signs
  • Coronary artery abnormalities
  • Kawasaki disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Complete and incomplete Kawasaki disease: Two sides of the same coin'. Together they form a unique fingerprint.

  • Cite this

    Manlhiot, C., Christie, E., McCrindle, B. W., Rosenberg, H., Chahal, N., & Yeung, R. S. M. (2012). Complete and incomplete Kawasaki disease: Two sides of the same coin. European Journal of Pediatrics, 171(4), 657-662. https://doi.org/10.1007/s00431-011-1631-2