TY - JOUR
T1 - Complementopathies and precision medicine
AU - Gavriilaki, Eleni
AU - Brodsky, Robert A.
N1 - Funding Information:
Given the broad scope of this Review, the authors often refer to specialized review articles rather than primary literature, and they have been able to include only selected examples of original work in the field. Therefore, the authors thank colleagues who are not specifically cited for their contribution and their understanding. EG is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme (Human Resources Development, Education and Lifelong Learning 2014-2020) (MIS 5033021), enabled through the State Scholarships Foundation. RB received funding support from NIH/NHLBI R01HL133113.
Funding Information:
Conflict of interest: RAB is a member of the scientific advisory board for and receives grant funding from Alexion Pharmaceuticals Inc. Copyright: © 2020, American Society for Clinical Investigation. Reference information: J Clin Invest. 2020;130(5):2152–2163. https://doi.org/10.1172/JCI136094.
Funding Information:
Given the broad scope of this Review, the authors often refer to specialized review articles rather than primary literature, and they have been able to include only selected examples of original work in the field. Therefore, the authors thank colleagues who are not specifically cited for their contribution and their understanding. EG is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Pro-gramme (Human Resources Development, Education and Lifelong Learning 2014-2020) (MIS 5033021), enabled through the State Scholarships Foundation. RB received funding support from NIH/NHLBI R01HL133113.
Publisher Copyright:
© 2020, American Society for Clinical Investigation.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - The renaissance of complement diagnostics and therapeutics has introduced precision medicine into a widened field of complement-mediated diseases. In particular, complement-mediated diseases (or complementopathies) with ongoing or published clinical trials of complement inhibitors include paroxysmal nocturnal hemoglobinuria, cold agglutinin disease, hemolytic uremic syndrome, nephropathies, HELLP syndrome, transplant-associated thrombotic microangiopathy, antiphospholipid antibody syndrome, myasthenia gravis, and neuromyelitis optica. Recognizing that this field is rapidly expanding, we aim to provide a state-of-the-art review of (a) current understanding of complement biology for the clinician, (b) novel insights into complement with potential applicability to clinical practice, (c) complement in disease across various disciplines (hematology, nephrology, obstetrics, transplantation, rheumatology, and neurology), and (d) the potential future of precision medicine. Better understanding of complement diagnostics and therapeutics will not only facilitate physicians treating patients in clinical practice but also provide the basis for future research toward precision medicine in this field.
AB - The renaissance of complement diagnostics and therapeutics has introduced precision medicine into a widened field of complement-mediated diseases. In particular, complement-mediated diseases (or complementopathies) with ongoing or published clinical trials of complement inhibitors include paroxysmal nocturnal hemoglobinuria, cold agglutinin disease, hemolytic uremic syndrome, nephropathies, HELLP syndrome, transplant-associated thrombotic microangiopathy, antiphospholipid antibody syndrome, myasthenia gravis, and neuromyelitis optica. Recognizing that this field is rapidly expanding, we aim to provide a state-of-the-art review of (a) current understanding of complement biology for the clinician, (b) novel insights into complement with potential applicability to clinical practice, (c) complement in disease across various disciplines (hematology, nephrology, obstetrics, transplantation, rheumatology, and neurology), and (d) the potential future of precision medicine. Better understanding of complement diagnostics and therapeutics will not only facilitate physicians treating patients in clinical practice but also provide the basis for future research toward precision medicine in this field.
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U2 - 10.1172/JCI136094
DO - 10.1172/JCI136094
M3 - Review article
C2 - 32310222
AN - SCOPUS:85084134458
SN - 0021-9738
VL - 130
SP - 2152
EP - 2163
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 5
ER -