Complement levels before and after dives with a high risk of DCS

Paul A Nyquist, R. Ball, M. J. Sheridan

Research output: Contribution to journalArticle

Abstract

Background: Previously, complement activation has been associated with decompression sickness (DCS). However data, both in humans and in animals, are controversial. Hypothesis: Complement activation and depletion occurs after exposure to the hyperbaric environment and is associated with increasing risk of DCS. Methods: We obtained serological samples from 102 dives (120-300 feet of seawater) with a constant partial pressure of O 2 set at 1.3 ATA in thirty-five U.S. Navy diver volunteers. Blood was obtained within one hour of diving and within one hour of surfacing. Plasma was extracted and analyzed for complement depletion. The risk of DCS was estimated using a validated model of DCS risk. Results: Pre-post dive concentrations of C3a were significantly related to estimated risk of DCS (Figure 1), but the variation in predicted DCS explained by C3a was small (correlation co-efficient (r 2 = 0.19, p

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalUndersea and Hyperbaric Medicine
Volume34
Issue number3
StatePublished - May 2007

Fingerprint

Decompression Sickness
decompression
complement
Complement Activation
volunteers
Diving
seawater
Partial Pressure
Seawater
diving
partial pressure
Volunteers
blood
plasma
animals
animal
sampling

ASJC Scopus subject areas

  • Physiology (medical)
  • Pulmonary and Respiratory Medicine
  • Aquatic Science
  • Medicine (miscellaneous)

Cite this

Complement levels before and after dives with a high risk of DCS. / Nyquist, Paul A; Ball, R.; Sheridan, M. J.

In: Undersea and Hyperbaric Medicine, Vol. 34, No. 3, 05.2007, p. 191-197.

Research output: Contribution to journalArticle

Nyquist, Paul A ; Ball, R. ; Sheridan, M. J. / Complement levels before and after dives with a high risk of DCS. In: Undersea and Hyperbaric Medicine. 2007 ; Vol. 34, No. 3. pp. 191-197.
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