Complement depletion in cryptococcal sepsis

A. M. Macher, J. E. Bennett, J. E. Gadek, M. M. Frank

Research output: Contribution to journalArticle

Abstract

Marked depletion of serum opsonins and complement (C) components was documented during cryptococcal septicemia in three patients. Phagocytic indices (PI) obtained with normal (nl) neutrophils and sera from these patients were 50) was 8 CN developed fungemia and died within 2 weeks. Their sera revealed depletion of serum opsonins and hypocomplementemia. Mean serum PI was 1.0 (nl 2.2 to 3.3) and mean CH50 was 99 (nl 150 to 300 units/ml). Heat-killed CN in intracardiac doses of 2x109 and 5x109 cells produced the same phenomenon acutely. Sera obtained at 60 min had PI of 0.7 and 1.1 and CH50 of 119 and 103. Depletion of serum C components accompanied CN fungemia in both man and experimentally infected guinea pigs. Yeast within the bloodstream may be the direct cause of hypocomplementemia. The resulting loss of serum opsonins may further impair the host's ability to contain the infection.

Original languageEnglish (US)
Pages (from-to)1686-1690
Number of pages5
JournalJournal of Immunology
Volume120
Issue number5
StatePublished - 1978
Externally publishedYes

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Sepsis
Opsonin Proteins
Serum
Fungemia
Guinea Pigs
Neutrophils
Hot Temperature
Yeasts
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Macher, A. M., Bennett, J. E., Gadek, J. E., & Frank, M. M. (1978). Complement depletion in cryptococcal sepsis. Journal of Immunology, 120(5), 1686-1690.

Complement depletion in cryptococcal sepsis. / Macher, A. M.; Bennett, J. E.; Gadek, J. E.; Frank, M. M.

In: Journal of Immunology, Vol. 120, No. 5, 1978, p. 1686-1690.

Research output: Contribution to journalArticle

Macher, AM, Bennett, JE, Gadek, JE & Frank, MM 1978, 'Complement depletion in cryptococcal sepsis', Journal of Immunology, vol. 120, no. 5, pp. 1686-1690.
Macher AM, Bennett JE, Gadek JE, Frank MM. Complement depletion in cryptococcal sepsis. Journal of Immunology. 1978;120(5):1686-1690.
Macher, A. M. ; Bennett, J. E. ; Gadek, J. E. ; Frank, M. M. / Complement depletion in cryptococcal sepsis. In: Journal of Immunology. 1978 ; Vol. 120, No. 5. pp. 1686-1690.
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