Complement and IL-12: Yin and yang

Christopher L. Karp; Marsha Wills-Karp

doi:10.1016/S1286-4579(00)01358-7

Complement and IL-12: Yin and yang

Christopher L. Karp, Marsha Wills-Karp

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.

Original language	English (US)
Pages (from-to)	109-119
Number of pages	11
Journal	Microbes and Infection
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S1286-4579(00)01358-7
State	Published - 2001
Externally published	Yes

Keywords

Complement
Interleukin 12
Monocyte

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/S1286-4579(00)01358-7

Cite this

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title = "Complement and IL-12: Yin and yang",

abstract = "Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.",

keywords = "Complement, Interleukin 12, Monocyte",

author = "Karp, {Christopher L.} and Marsha Wills-Karp",

note = "Funding Information: This work was supported in part by NIH grants AI01223, AI40507, DE12167 (to C.K.), and ES09606, HL58527 (to M.W.-K.) Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1016/S1286-4579(00)01358-7",

language = "English (US)",

volume = "3",

pages = "109--119",

journal = "Microbes and Infection",

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T1 - Complement and IL-12

T2 - Yin and yang

AU - Karp, Christopher L.

AU - Wills-Karp, Marsha

N1 - Funding Information: This work was supported in part by NIH grants AI01223, AI40507, DE12167 (to C.K.), and ES09606, HL58527 (to M.W.-K.) Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.

AB - Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.

KW - Complement

KW - Interleukin 12

KW - Monocyte

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UR - http://www.scopus.com/inward/citedby.url?scp=0035089732&partnerID=8YFLogxK

U2 - 10.1016/S1286-4579(00)01358-7

DO - 10.1016/S1286-4579(00)01358-7

M3 - Review article

C2 - 11251297

AN - SCOPUS:0035089732

SN - 1286-4579

VL - 3

SP - 109

EP - 119

JO - Microbes and Infection

JF - Microbes and Infection

IS - 2

ER -

Complement and IL-12: Yin and yang

Abstract

Keywords

ASJC Scopus subject areas

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