Complement and IL-12: Yin and yang

Christopher L. Karp, Marsha Wills-Karp

Research output: Contribution to journalReview article


Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalMicrobes and Infection
Issue number2
StatePublished - Jan 1 2001



  • Complement
  • Interleukin 12
  • Monocyte

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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