Complement: A key system for immune surveillance and homeostasis

Daniel Ricklin, George Hajishengallis, Kun Yang, John D. Lambris

Research output: Contribution to journalReview article

Abstract

Nearly a century after the significance of the human complement system was recognized, we have come to realize that its functions extend far beyond the elimination of microbes. Complement acts as a rapid and efficient immune surveillance system that has distinct effects on healthy and altered host cells and foreign intruders. By eliminating cellular debris and infectious microbes, orchestrating immune responses and sending 'danger' signals, complement contributes substantially to homeostasis, but it can also take action against healthy cells if not properly controlled. This review describes our updated view of the function, structure and dynamics of the complement network, highlights its interconnection with immunity at large and with other endogenous pathways, and illustrates its multiple roles in homeostasis and disease.

Original languageEnglish (US)
Pages (from-to)785-797
Number of pages13
JournalNature Immunology
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Complement: A key system for immune surveillance and homeostasis'. Together they form a unique fingerprint.

  • Cite this