Abstract
There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-291 |
| Number of pages | 13 |
| Journal | Theoretical Medicine |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - Oct 1984 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Medicine (miscellaneous)
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Compensatory neoplasia : Chronic erythrocytosis and neuroblastic tumors. / de la Monte, Suzanne M.; Hutchins, Grover M.; Moore, G. William.
In: Theoretical Medicine, Vol. 5, No. 3, 10.1984, p. 279-291.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Compensatory neoplasia
T2 - Chronic erythrocytosis and neuroblastic tumors
AU - de la Monte, Suzanne M.
AU - Hutchins, Grover M.
AU - Moore, G. William
PY - 1984/10
Y1 - 1984/10
N2 - There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.
AB - There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.
UR - http://www.scopus.com/inward/record.url?scp=0021501422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021501422&partnerID=8YFLogxK
U2 - 10.1007/BF00489476
DO - 10.1007/BF00489476
M3 - Article
C2 - 6399636
AN - SCOPUS:0021501422
VL - 5
SP - 279
EP - 291
JO - Theoretical Medicine and Bioethics
JF - Theoretical Medicine and Bioethics
SN - 1386-7415
IS - 3
ER -