Compensatory neoplasia: Chronic erythrocytosis and neuroblastic tumors

Suzanne M. de la Monte, Grover M. Hutchins, G. William Moore

    Research output: Contribution to journalArticle

    Abstract

    There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.

    Original languageEnglish (US)
    Pages (from-to)279-291
    Number of pages13
    JournalTheoretical Medicine
    Volume5
    Issue number3
    DOIs
    StatePublished - Oct 1984

    ASJC Scopus subject areas

    • Public Health, Environmental and Occupational Health
    • Medicine (miscellaneous)

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