Compensatory neoplasia: Chronic erythrocytosis and neuroblastic tumors

Suzanne M. de la Monte; Grover M. Hutchins; G. William Moore

doi:10.1007/BF00489476

Compensatory neoplasia: Chronic erythrocytosis and neuroblastic tumors

Suzanne M. de la Monte, Grover M. Hutchins, G. William Moore

Research output: Contribution to journal › Article › peer-review

Abstract

There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.

Original language	English (US)
Pages (from-to)	279-291
Number of pages	13
Journal	Theoretical Medicine
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/BF00489476
State	Published - Oct 1984

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Medicine (miscellaneous)

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author = "{de la Monte}, {Suzanne M.} and Hutchins, {Grover M.} and Moore, {G. William}",

year = "1984",

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AU - Moore, G. William

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Y1 - 1984/10

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AB - There are a large number of exogenous biological and chemical substances with known neoplastic or carcinogenic potential. However, it has also been postulated that external stimuli can influence the body's internal milieu, and thereby induce compensatory excessive growth of cells in the form of hyperplasia or neoplasia. In a recent study, we observed a strong association between chronic hypoxic states and the occurrence of peripheral neuroblastic tumors, a relatively uncommon group of neural neoplasms. In this report we review those findings and formulate an hypothesis to explain why conditions which lead to chronic erythrocytosis may also cause compensatory neoplasia of neural tissues.

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Compensatory neoplasia: Chronic erythrocytosis and neuroblastic tumors

Abstract

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