Compensation for spill-in and spill-out partial volume effects in cardiac PET imaging

Yong Du, Igal Madar, Martin J Stumpf, Xing Rong, George S K Fung, Eric Frey

Research output: Contribution to journalArticle

Abstract

Background: Partial volume effects (PVEs) in PET imaging result in incorrect regional activity estimates due to both spill-out and spill-in from activity in neighboring regions. It is important to compensate for both effects to achieve accurate quantification. In this study, an image-based partial volume compensation (PVC) method was developed and validated for cardiac PET. Methods and Results: The method uses volume-of-interest (VOI) maps segmented from contrast-enhanced CTA images to compensate for both spill-in and spill-out in each VOI. The PVC method was validated with simulation studies and also applied to images of dog cardiac perfusion PET data. The PV effects resulting from cardiac motion and myocardial uptake defects were investigated and the efficacy of the proposed PVC method in compensating for these effects was evaluated. Results: Results indicate that the magnitude and the direction of PVEs in cardiac imaging change over time. This affects the accuracy of activity distributions estimates obtained during dynamic studies. The defect regions have different PVEs as compared to the normal myocardium. Cardiac motion contributes around 10% to the PVEs. PVC effectively removed both spill-in and spill-out in cardiac imaging. Conclusions: PVC improved left ventricular wall uniformity and quantitative accuracy. The best strategy for PVC was to compensate for the PVEs in each cardiac phase independently and treat severe uptake defects as independent regions from the normal myocardium.

Original languageEnglish (US)
Pages (from-to)84-98
Number of pages15
JournalJournal of Nuclear Cardiology
Volume20
Issue number1
DOIs
StatePublished - Feb 2013

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Myocardium
Perfusion
Dogs
Direction compound

Keywords

  • cardiac PET imaging
  • Partial volume compensation
  • spill-in and spill-out

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Compensation for spill-in and spill-out partial volume effects in cardiac PET imaging. / Du, Yong; Madar, Igal; Stumpf, Martin J; Rong, Xing; Fung, George S K; Frey, Eric.

In: Journal of Nuclear Cardiology, Vol. 20, No. 1, 02.2013, p. 84-98.

Research output: Contribution to journalArticle

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