Compensating for patient respiration in PET/CT imaging with the registered and summed phases (RASP) procedure

Paul Kindhan, Lawrence MacDonald, Lydia Ng, Adam Alessio, Paul Segars, Benjamin Tsui, Sayan Pathak

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

PET/CT imaging has introduced new challenges in accurate quantitation of lung nodules due to respiratory motion and mismatches in CT-based attenuation correction (CTAC). We used Monte Carlo simulations to investigate how respiratory-correlated CTAC can be optimized to account for mis-registration between the AC data and the PET data due to respiratory motion. This step also allows compensating for increased emission noise in respiratory respiratory-gated PET images by non-rigid image registration of the CTAC phases. These registration parameters are then applied to the attenuation-corrected PET phase images, which are then summed to reduce noise. A significant increase in the final PET SNR is demonstrated.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages1104-1107
Number of pages4
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

ASJC Scopus subject areas

  • Engineering(all)

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    Kindhan, P., MacDonald, L., Ng, L., Alessio, A., Segars, P., Tsui, B., & Pathak, S. (2006). Compensating for patient respiration in PET/CT imaging with the registered and summed phases (RASP) procedure. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 1104-1107). [1625115] (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006).