Compatibility testing problems associated with bovine thrombintreated plasma

Rosetta Sue Shirey; Ana B. Ciappi; Thomas S. Kickler; Darrell Triulzi; Paul M. Ness

doi:10.21307/IMMUNOHEMATOLOGY-2019-951

Compatibility testing problems associated with bovine thrombintreated plasma

Rosetta Sue Shirey, Ana B. Ciappi, Thomas S. Kickler, Darrell Triulzi, Paul M. Ness

School of Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombinassociated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.

Original language	English (US)
Pages (from-to)	19-21
Number of pages	3
Journal	Immunohematology
Volume	9
Issue number	1
DOIs	https://doi.org/10.21307/IMMUNOHEMATOLOGY-2019-951
State	Published - Mar 1993

ASJC Scopus subject areas

General Medicine

Access to Document

10.21307/IMMUNOHEMATOLOGY-2019-951

Cite this

@article{4bfb7a64bf2d46e2911027a449f1829b,

title = "Compatibility testing problems associated with bovine thrombintreated plasma",

abstract = "Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombinassociated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.",

author = "{Sue Shirey}, Rosetta and Ciappi, {Ana B.} and Kickler, {Thomas S.} and Darrell Triulzi and Ness, {Paul M.}",

year = "1993",

month = mar,

doi = "10.21307/IMMUNOHEMATOLOGY-2019-951",

language = "English (US)",

volume = "9",

pages = "19--21",

journal = "Immunohematology",

issn = "0894-203X",

publisher = "American Red Cross",

number = "1",

}

TY - JOUR

T1 - Compatibility testing problems associated with bovine thrombintreated plasma

AU - Sue Shirey, Rosetta

AU - Ciappi, Ana B.

AU - Kickler, Thomas S.

AU - Triulzi, Darrell

AU - Ness, Paul M.

PY - 1993/3

Y1 - 1993/3

N2 - Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombinassociated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.

AB - Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombinassociated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.

UR - http://www.scopus.com/inward/record.url?scp=0027395964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027395964&partnerID=8YFLogxK

U2 - 10.21307/IMMUNOHEMATOLOGY-2019-951

DO - 10.21307/IMMUNOHEMATOLOGY-2019-951

M3 - Article

C2 - 15946081

AN - SCOPUS:0027395964

SN - 0894-203X

VL - 9

SP - 19

EP - 21

JO - Immunohematology

JF - Immunohematology

IS - 1

ER -

Compatibility testing problems associated with bovine thrombintreated plasma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this