TY - JOUR
T1 - Comparison of Visual Outcomes in Coats’ Disease
T2 - A 20-Year Experience
AU - Ong, Sally S.
AU - Buckley, Edward G.
AU - McCuen, Brooks W.
AU - Jaffe, Glenn J.
AU - Postel, Eric A.
AU - Mahmoud, Tamer H.
AU - Stinnett, Sandra S.
AU - Toth, Cynthia A.
AU - Vajzovic, Lejla
AU - Mruthyunjaya, Prithvi
N1 - Publisher Copyright:
© 2017 American Academy of Ophthalmology
PY - 2017/9
Y1 - 2017/9
N2 - Purpose To report differences in visual acuities among patients with Coats’ disease who sought treatment at a tertiary care university-based practice. Design Single-center retrospective cohort study. Participants Patients with Coats’ disease diagnosed clinically, angiographically, or both from 1995 through 2015. Methods Patients were divided into 2 groups based on date of presentation: decade 1 (1995–2005) and decade 2 (2006–2015). Main Outcome Measures Visual acuity (VA). Results Thirty-nine eyes of 39 patients were included with 19 eyes presenting in decade 1 and 20 eyes presenting in decade 2. Three patients demonstrated bilateral disease, but only the worse eye was included for analysis. Forty-seven percent of eyes in decade 1 demonstrated advanced stages of disease (stage 3B or worse) compared with 20% of eyes in decade 2. There was a trend for the mean initial presenting VA (±standard deviation) for decade 1 eyes to be worse (2.05±1.29 logarithm of the minimum angle of resolution [logMAR]) than for decade 2 eyes (1.45±0.99 logMAR; P = 0.1). From initial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stable for decade 2 eyes (P = 1.0). At the end of follow-up, there was a trend for mean VA for decade 1 eyes (2.28±1.17 logMAR) to be worse than for decade 2 eyes (1.60±1.15 logMAR; P = 0.07). Eight eyes were observed initially in decade 1 compared with 1 eye in decade 2, and only 1 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation. Decade 2 eyes had a higher average number of procedures per eye (6.5±4.9) compared with decade 1 eyes (1.4±1.7; P < 0.001). Conclusions The earlier presentation of disease in decade 2 suggests improvements in disease detection over time. Furthermore, there was a trend for eyes to have better final VA in this decade. This is due to a combination of factors, including earlier presentation of disease, fewer eyes being observed without treatment, and eyes, when treated, receiving a higher number of procedures.
AB - Purpose To report differences in visual acuities among patients with Coats’ disease who sought treatment at a tertiary care university-based practice. Design Single-center retrospective cohort study. Participants Patients with Coats’ disease diagnosed clinically, angiographically, or both from 1995 through 2015. Methods Patients were divided into 2 groups based on date of presentation: decade 1 (1995–2005) and decade 2 (2006–2015). Main Outcome Measures Visual acuity (VA). Results Thirty-nine eyes of 39 patients were included with 19 eyes presenting in decade 1 and 20 eyes presenting in decade 2. Three patients demonstrated bilateral disease, but only the worse eye was included for analysis. Forty-seven percent of eyes in decade 1 demonstrated advanced stages of disease (stage 3B or worse) compared with 20% of eyes in decade 2. There was a trend for the mean initial presenting VA (±standard deviation) for decade 1 eyes to be worse (2.05±1.29 logarithm of the minimum angle of resolution [logMAR]) than for decade 2 eyes (1.45±0.99 logMAR; P = 0.1). From initial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stable for decade 2 eyes (P = 1.0). At the end of follow-up, there was a trend for mean VA for decade 1 eyes (2.28±1.17 logMAR) to be worse than for decade 2 eyes (1.60±1.15 logMAR; P = 0.07). Eight eyes were observed initially in decade 1 compared with 1 eye in decade 2, and only 1 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation. Decade 2 eyes had a higher average number of procedures per eye (6.5±4.9) compared with decade 1 eyes (1.4±1.7; P < 0.001). Conclusions The earlier presentation of disease in decade 2 suggests improvements in disease detection over time. Furthermore, there was a trend for eyes to have better final VA in this decade. This is due to a combination of factors, including earlier presentation of disease, fewer eyes being observed without treatment, and eyes, when treated, receiving a higher number of procedures.
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U2 - 10.1016/j.ophtha.2017.03.051
DO - 10.1016/j.ophtha.2017.03.051
M3 - Article
C2 - 28461016
AN - SCOPUS:85018348359
SN - 0161-6420
VL - 124
SP - 1368
EP - 1376
JO - Ophthalmology
JF - Ophthalmology
IS - 9
ER -