Comparison of Visual Outcomes in Coats’ Disease: A 20-Year Experience

Sally Ong, Edward G. Buckley, Brooks W. McCuen, Glenn J. Jaffe, Eric A. Postel, Tamer H. Mahmoud, Sandra S. Stinnett, Cynthia A. Toth, Lejla Vajzovic, Prithvi Mruthyunjaya

Research output: Contribution to journalArticle

Abstract

Purpose To report differences in visual acuities among patients with Coats’ disease who sought treatment at a tertiary care university-based practice. Design Single-center retrospective cohort study. Participants Patients with Coats’ disease diagnosed clinically, angiographically, or both from 1995 through 2015. Methods Patients were divided into 2 groups based on date of presentation: decade 1 (1995–2005) and decade 2 (2006–2015). Main Outcome Measures Visual acuity (VA). Results Thirty-nine eyes of 39 patients were included with 19 eyes presenting in decade 1 and 20 eyes presenting in decade 2. Three patients demonstrated bilateral disease, but only the worse eye was included for analysis. Forty-seven percent of eyes in decade 1 demonstrated advanced stages of disease (stage 3B or worse) compared with 20% of eyes in decade 2. There was a trend for the mean initial presenting VA (±standard deviation) for decade 1 eyes to be worse (2.05±1.29 logarithm of the minimum angle of resolution [logMAR]) than for decade 2 eyes (1.45±0.99 logMAR; P = 0.1). From initial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stable for decade 2 eyes (P = 1.0). At the end of follow-up, there was a trend for mean VA for decade 1 eyes (2.28±1.17 logMAR) to be worse than for decade 2 eyes (1.60±1.15 logMAR; P = 0.07). Eight eyes were observed initially in decade 1 compared with 1 eye in decade 2, and only 1 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation. Decade 2 eyes had a higher average number of procedures per eye (6.5±4.9) compared with decade 1 eyes (1.4±1.7; P < 0.001). Conclusions The earlier presentation of disease in decade 2 suggests improvements in disease detection over time. Furthermore, there was a trend for eyes to have better final VA in this decade. This is due to a combination of factors, including earlier presentation of disease, fewer eyes being observed without treatment, and eyes, when treated, receiving a higher number of procedures.

Original languageEnglish (US)
Pages (from-to)1368-1376
Number of pages9
JournalOphthalmology
Volume124
Issue number9
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Fingerprint

Retinal Telangiectasis
Visual Acuity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ong, S., Buckley, E. G., McCuen, B. W., Jaffe, G. J., Postel, E. A., Mahmoud, T. H., ... Mruthyunjaya, P. (2017). Comparison of Visual Outcomes in Coats’ Disease: A 20-Year Experience. Ophthalmology, 124(9), 1368-1376. https://doi.org/10.1016/j.ophtha.2017.03.051

Comparison of Visual Outcomes in Coats’ Disease : A 20-Year Experience. / Ong, Sally; Buckley, Edward G.; McCuen, Brooks W.; Jaffe, Glenn J.; Postel, Eric A.; Mahmoud, Tamer H.; Stinnett, Sandra S.; Toth, Cynthia A.; Vajzovic, Lejla; Mruthyunjaya, Prithvi.

In: Ophthalmology, Vol. 124, No. 9, 01.09.2017, p. 1368-1376.

Research output: Contribution to journalArticle

Ong, S, Buckley, EG, McCuen, BW, Jaffe, GJ, Postel, EA, Mahmoud, TH, Stinnett, SS, Toth, CA, Vajzovic, L & Mruthyunjaya, P 2017, 'Comparison of Visual Outcomes in Coats’ Disease: A 20-Year Experience', Ophthalmology, vol. 124, no. 9, pp. 1368-1376. https://doi.org/10.1016/j.ophtha.2017.03.051
Ong S, Buckley EG, McCuen BW, Jaffe GJ, Postel EA, Mahmoud TH et al. Comparison of Visual Outcomes in Coats’ Disease: A 20-Year Experience. Ophthalmology. 2017 Sep 1;124(9):1368-1376. https://doi.org/10.1016/j.ophtha.2017.03.051
Ong, Sally ; Buckley, Edward G. ; McCuen, Brooks W. ; Jaffe, Glenn J. ; Postel, Eric A. ; Mahmoud, Tamer H. ; Stinnett, Sandra S. ; Toth, Cynthia A. ; Vajzovic, Lejla ; Mruthyunjaya, Prithvi. / Comparison of Visual Outcomes in Coats’ Disease : A 20-Year Experience. In: Ophthalmology. 2017 ; Vol. 124, No. 9. pp. 1368-1376.
@article{69f26b1e740a4a78a8602433d7501f90,
title = "Comparison of Visual Outcomes in Coats’ Disease: A 20-Year Experience",
abstract = "Purpose To report differences in visual acuities among patients with Coats’ disease who sought treatment at a tertiary care university-based practice. Design Single-center retrospective cohort study. Participants Patients with Coats’ disease diagnosed clinically, angiographically, or both from 1995 through 2015. Methods Patients were divided into 2 groups based on date of presentation: decade 1 (1995–2005) and decade 2 (2006–2015). Main Outcome Measures Visual acuity (VA). Results Thirty-nine eyes of 39 patients were included with 19 eyes presenting in decade 1 and 20 eyes presenting in decade 2. Three patients demonstrated bilateral disease, but only the worse eye was included for analysis. Forty-seven percent of eyes in decade 1 demonstrated advanced stages of disease (stage 3B or worse) compared with 20{\%} of eyes in decade 2. There was a trend for the mean initial presenting VA (±standard deviation) for decade 1 eyes to be worse (2.05±1.29 logarithm of the minimum angle of resolution [logMAR]) than for decade 2 eyes (1.45±0.99 logMAR; P = 0.1). From initial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stable for decade 2 eyes (P = 1.0). At the end of follow-up, there was a trend for mean VA for decade 1 eyes (2.28±1.17 logMAR) to be worse than for decade 2 eyes (1.60±1.15 logMAR; P = 0.07). Eight eyes were observed initially in decade 1 compared with 1 eye in decade 2, and only 1 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation. Decade 2 eyes had a higher average number of procedures per eye (6.5±4.9) compared with decade 1 eyes (1.4±1.7; P < 0.001). Conclusions The earlier presentation of disease in decade 2 suggests improvements in disease detection over time. Furthermore, there was a trend for eyes to have better final VA in this decade. This is due to a combination of factors, including earlier presentation of disease, fewer eyes being observed without treatment, and eyes, when treated, receiving a higher number of procedures.",
author = "Sally Ong and Buckley, {Edward G.} and McCuen, {Brooks W.} and Jaffe, {Glenn J.} and Postel, {Eric A.} and Mahmoud, {Tamer H.} and Stinnett, {Sandra S.} and Toth, {Cynthia A.} and Lejla Vajzovic and Prithvi Mruthyunjaya",
year = "2017",
month = "9",
day = "1",
doi = "10.1016/j.ophtha.2017.03.051",
language = "English (US)",
volume = "124",
pages = "1368--1376",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Comparison of Visual Outcomes in Coats’ Disease

T2 - A 20-Year Experience

AU - Ong, Sally

AU - Buckley, Edward G.

AU - McCuen, Brooks W.

AU - Jaffe, Glenn J.

AU - Postel, Eric A.

AU - Mahmoud, Tamer H.

AU - Stinnett, Sandra S.

AU - Toth, Cynthia A.

AU - Vajzovic, Lejla

AU - Mruthyunjaya, Prithvi

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Purpose To report differences in visual acuities among patients with Coats’ disease who sought treatment at a tertiary care university-based practice. Design Single-center retrospective cohort study. Participants Patients with Coats’ disease diagnosed clinically, angiographically, or both from 1995 through 2015. Methods Patients were divided into 2 groups based on date of presentation: decade 1 (1995–2005) and decade 2 (2006–2015). Main Outcome Measures Visual acuity (VA). Results Thirty-nine eyes of 39 patients were included with 19 eyes presenting in decade 1 and 20 eyes presenting in decade 2. Three patients demonstrated bilateral disease, but only the worse eye was included for analysis. Forty-seven percent of eyes in decade 1 demonstrated advanced stages of disease (stage 3B or worse) compared with 20% of eyes in decade 2. There was a trend for the mean initial presenting VA (±standard deviation) for decade 1 eyes to be worse (2.05±1.29 logarithm of the minimum angle of resolution [logMAR]) than for decade 2 eyes (1.45±0.99 logMAR; P = 0.1). From initial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stable for decade 2 eyes (P = 1.0). At the end of follow-up, there was a trend for mean VA for decade 1 eyes (2.28±1.17 logMAR) to be worse than for decade 2 eyes (1.60±1.15 logMAR; P = 0.07). Eight eyes were observed initially in decade 1 compared with 1 eye in decade 2, and only 1 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation. Decade 2 eyes had a higher average number of procedures per eye (6.5±4.9) compared with decade 1 eyes (1.4±1.7; P < 0.001). Conclusions The earlier presentation of disease in decade 2 suggests improvements in disease detection over time. Furthermore, there was a trend for eyes to have better final VA in this decade. This is due to a combination of factors, including earlier presentation of disease, fewer eyes being observed without treatment, and eyes, when treated, receiving a higher number of procedures.

AB - Purpose To report differences in visual acuities among patients with Coats’ disease who sought treatment at a tertiary care university-based practice. Design Single-center retrospective cohort study. Participants Patients with Coats’ disease diagnosed clinically, angiographically, or both from 1995 through 2015. Methods Patients were divided into 2 groups based on date of presentation: decade 1 (1995–2005) and decade 2 (2006–2015). Main Outcome Measures Visual acuity (VA). Results Thirty-nine eyes of 39 patients were included with 19 eyes presenting in decade 1 and 20 eyes presenting in decade 2. Three patients demonstrated bilateral disease, but only the worse eye was included for analysis. Forty-seven percent of eyes in decade 1 demonstrated advanced stages of disease (stage 3B or worse) compared with 20% of eyes in decade 2. There was a trend for the mean initial presenting VA (±standard deviation) for decade 1 eyes to be worse (2.05±1.29 logarithm of the minimum angle of resolution [logMAR]) than for decade 2 eyes (1.45±0.99 logMAR; P = 0.1). From initial to final follow-up visit, mean VA also worsened for decade 1 eyes (P = 0.03), but remained stable for decade 2 eyes (P = 1.0). At the end of follow-up, there was a trend for mean VA for decade 1 eyes (2.28±1.17 logMAR) to be worse than for decade 2 eyes (1.60±1.15 logMAR; P = 0.07). Eight eyes were observed initially in decade 1 compared with 1 eye in decade 2, and only 1 of the observed eyes (in decade 2) developed painful glaucoma requiring enucleation. Decade 2 eyes had a higher average number of procedures per eye (6.5±4.9) compared with decade 1 eyes (1.4±1.7; P < 0.001). Conclusions The earlier presentation of disease in decade 2 suggests improvements in disease detection over time. Furthermore, there was a trend for eyes to have better final VA in this decade. This is due to a combination of factors, including earlier presentation of disease, fewer eyes being observed without treatment, and eyes, when treated, receiving a higher number of procedures.

UR - http://www.scopus.com/inward/record.url?scp=85018348359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018348359&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2017.03.051

DO - 10.1016/j.ophtha.2017.03.051

M3 - Article

C2 - 28461016

AN - SCOPUS:85018348359

VL - 124

SP - 1368

EP - 1376

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 9

ER -