Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients

J. Javier Provencio, Pia Kivisäkk, Barbara H. Tucky, Mark G. Luciano, Richard M. Ransohoff

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present study was to define the cellular composition of ventricular, as compared with lumbar, cerebrospinal fluid (CSF) in patients with non-inflammatory neurological disorders (NIND). We addressed this issue by determining the cellular composition of lumbar CSF from patients with normal pressure hydrocephalus (NPH) who were undergoing lumbar CSF drainage during evaluation for shunting procedures, and evaluating ventricular CSF from a subset of these who underwent subsequent placement of ventriculoperitoneal shunts. We determined the cellular composition of lumbar CSF from 18 patients with NPH, and found that the leukocyte differentials, and relative proportions of CD4 + and CD8+ central memory (TCM), effector memory (TEM) and naïve cell (TNaive) populations, were equivalent to those found previously in studies of CSF from patients with NIND. We further evaluated cells in the ventricular CSF of five patients who had previously undergone lumbar drainage. Leukocyte differential counts, as well as CD4+ and CD8+ TCM, TEM, and T Naive proportions, were equivalent in matched ventricular and lumbar CSF samples. These observations support the hypothesis that leukocytes enter the CSF in a selective fashion, at its site of formation in the choroid plexus. The results implicate CSF T cells in the immune surveillance of the central nervous system.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalJournal of Neuroimmunology
Volume163
Issue number1-2
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Keywords

  • Cerebrospinal fluid
  • Immune surveillance
  • Lymphocytes
  • Non-inflammatory
  • Ventriculoperitoneal shunt

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Comparison of ventricular and lumbar cerebrospinal fluid T cells in non-inflammatory neurological disorder (NIND) patients'. Together they form a unique fingerprint.

Cite this