Comparison of two regimens of feeding and oral electrolyte solutions in infants with diarrhea

Julius G. Goepp, Scott Katz, Elizabeth Cuervo, Raymond Reid, J. Roberto Moran, Mathuram Santosham

Research output: Contribution to journalArticle

Abstract

Background: Glucose-based oral rehydration solutions (ORS) available in the United States do not appear to reduce the severity or duration of diarrhea. The use of cereal-derived ORS and cereal-based feedings appears to diminish the severity of illness in studies conducted in the developing world. To our knowledge, no controlled trials of cereal-derived ORS or cereal-based feedings have been performed in the United States. Methods: We performed a randomized, double-blind trial of two ORS feeding regimens in outpatients with diarrhea. Patients aged 2-13 months with acute watery diarrhea were enrolled. Subjects received standard glucose-based ORS in alternation with soy-based, lactose-free infant formula (Group 1) or rice syrup solid containing ORS in alternation with rice-based, lactose-free infant formula (Group 2). Subjects were visited at home daily to determine the severity of illness and characteristics of the stool. Results: After the first 2 days, significantly more Group 1 subjects continued to have diarrhea than did Group 2 subjects (median duration of diarrhea 3 vs. 2 days) as demonstrated by Kaplan-Meier survival curves (p = 0.04). Conclusion: We conclude that infants fed a regimen consisting of rice syrup solid containing ORS and rice formula resolved their diarrhea sooner than did infants fed a regimen of standard glucose-based ORS with soy formula. The relative contributions of ORS and formula to this more rapid recovery can be elucidated by further studies.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume24
Issue number4
DOIs
StatePublished - Apr 1997

Fingerprint

Rehydration Solutions
oral rehydration
Fluid Therapy
Electrolytes
electrolytes
Diarrhea
diarrhea
mouth
rice
Infant Formula
syrups
infant formulas
Lactose
Glucose
glucose
lactose
duration
Kaplan-Meier Estimate
Outpatients

Keywords

  • Cereal
  • Dehydration
  • Diarrhea
  • Oral rehydration solutions
  • Rehydration

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Comparison of two regimens of feeding and oral electrolyte solutions in infants with diarrhea. / Goepp, Julius G.; Katz, Scott; Cuervo, Elizabeth; Reid, Raymond; Moran, J. Roberto; Santosham, Mathuram.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 24, No. 4, 04.1997, p. 374-379.

Research output: Contribution to journalArticle

@article{b8d4b0b994094de2a7897b322e1c52bf,
title = "Comparison of two regimens of feeding and oral electrolyte solutions in infants with diarrhea",
abstract = "Background: Glucose-based oral rehydration solutions (ORS) available in the United States do not appear to reduce the severity or duration of diarrhea. The use of cereal-derived ORS and cereal-based feedings appears to diminish the severity of illness in studies conducted in the developing world. To our knowledge, no controlled trials of cereal-derived ORS or cereal-based feedings have been performed in the United States. Methods: We performed a randomized, double-blind trial of two ORS feeding regimens in outpatients with diarrhea. Patients aged 2-13 months with acute watery diarrhea were enrolled. Subjects received standard glucose-based ORS in alternation with soy-based, lactose-free infant formula (Group 1) or rice syrup solid containing ORS in alternation with rice-based, lactose-free infant formula (Group 2). Subjects were visited at home daily to determine the severity of illness and characteristics of the stool. Results: After the first 2 days, significantly more Group 1 subjects continued to have diarrhea than did Group 2 subjects (median duration of diarrhea 3 vs. 2 days) as demonstrated by Kaplan-Meier survival curves (p = 0.04). Conclusion: We conclude that infants fed a regimen consisting of rice syrup solid containing ORS and rice formula resolved their diarrhea sooner than did infants fed a regimen of standard glucose-based ORS with soy formula. The relative contributions of ORS and formula to this more rapid recovery can be elucidated by further studies.",
keywords = "Cereal, Dehydration, Diarrhea, Oral rehydration solutions, Rehydration",
author = "Goepp, {Julius G.} and Scott Katz and Elizabeth Cuervo and Raymond Reid and Moran, {J. Roberto} and Mathuram Santosham",
year = "1997",
month = "4",
doi = "10.1097/00005176-199704000-00004",
language = "English (US)",
volume = "24",
pages = "374--379",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Comparison of two regimens of feeding and oral electrolyte solutions in infants with diarrhea

AU - Goepp, Julius G.

AU - Katz, Scott

AU - Cuervo, Elizabeth

AU - Reid, Raymond

AU - Moran, J. Roberto

AU - Santosham, Mathuram

PY - 1997/4

Y1 - 1997/4

N2 - Background: Glucose-based oral rehydration solutions (ORS) available in the United States do not appear to reduce the severity or duration of diarrhea. The use of cereal-derived ORS and cereal-based feedings appears to diminish the severity of illness in studies conducted in the developing world. To our knowledge, no controlled trials of cereal-derived ORS or cereal-based feedings have been performed in the United States. Methods: We performed a randomized, double-blind trial of two ORS feeding regimens in outpatients with diarrhea. Patients aged 2-13 months with acute watery diarrhea were enrolled. Subjects received standard glucose-based ORS in alternation with soy-based, lactose-free infant formula (Group 1) or rice syrup solid containing ORS in alternation with rice-based, lactose-free infant formula (Group 2). Subjects were visited at home daily to determine the severity of illness and characteristics of the stool. Results: After the first 2 days, significantly more Group 1 subjects continued to have diarrhea than did Group 2 subjects (median duration of diarrhea 3 vs. 2 days) as demonstrated by Kaplan-Meier survival curves (p = 0.04). Conclusion: We conclude that infants fed a regimen consisting of rice syrup solid containing ORS and rice formula resolved their diarrhea sooner than did infants fed a regimen of standard glucose-based ORS with soy formula. The relative contributions of ORS and formula to this more rapid recovery can be elucidated by further studies.

AB - Background: Glucose-based oral rehydration solutions (ORS) available in the United States do not appear to reduce the severity or duration of diarrhea. The use of cereal-derived ORS and cereal-based feedings appears to diminish the severity of illness in studies conducted in the developing world. To our knowledge, no controlled trials of cereal-derived ORS or cereal-based feedings have been performed in the United States. Methods: We performed a randomized, double-blind trial of two ORS feeding regimens in outpatients with diarrhea. Patients aged 2-13 months with acute watery diarrhea were enrolled. Subjects received standard glucose-based ORS in alternation with soy-based, lactose-free infant formula (Group 1) or rice syrup solid containing ORS in alternation with rice-based, lactose-free infant formula (Group 2). Subjects were visited at home daily to determine the severity of illness and characteristics of the stool. Results: After the first 2 days, significantly more Group 1 subjects continued to have diarrhea than did Group 2 subjects (median duration of diarrhea 3 vs. 2 days) as demonstrated by Kaplan-Meier survival curves (p = 0.04). Conclusion: We conclude that infants fed a regimen consisting of rice syrup solid containing ORS and rice formula resolved their diarrhea sooner than did infants fed a regimen of standard glucose-based ORS with soy formula. The relative contributions of ORS and formula to this more rapid recovery can be elucidated by further studies.

KW - Cereal

KW - Dehydration

KW - Diarrhea

KW - Oral rehydration solutions

KW - Rehydration

UR - http://www.scopus.com/inward/record.url?scp=0031002001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031002001&partnerID=8YFLogxK

U2 - 10.1097/00005176-199704000-00004

DO - 10.1097/00005176-199704000-00004

M3 - Article

C2 - 9144118

AN - SCOPUS:0031002001

VL - 24

SP - 374

EP - 379

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 4

ER -