Comparison of two assays for measuring LDL cholesterol

Anirban Maitra, Shaina V. Hirany, Ishwarlal Jialal

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to evaluate the LipiDirect assay (L-LDL) against the Direct LDL(TM) immunoseparation method (D-LDL) and beta quantification (BQ-LDL) for measurement of LDL cholesterol (LDL-C) in patients with normo- and hypertriglyceridemia. Samples from 156 patients [triglyceride (Tg) range 0.61-9.95 g/L] were assayed for LDL-C concentrations with the three methods. An additional seven patients with type III hyperlipidemia and 25 paired sera from fasting and nonfasting individuals also were analyzed by the three methods. Both assays displayed excellent precision. The mean LDL-C value from L-LDL was significantly higher than BQ- LDL and D-LDL in normo- and hypertriglyceridemic samples (P

Original languageEnglish (US)
Pages (from-to)1040-1047
Number of pages8
JournalClinical Chemistry
Volume43
Issue number6
StatePublished - 1997
Externally publishedYes

Keywords

  • Beta quantification
  • Coronary artery disease
  • Hypertriglyceridemia
  • Immunoseparation

ASJC Scopus subject areas

  • Clinical Biochemistry

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