Comparison of trimethoprim sulfamethoxazole and amoxicillin in therapy of chloramphenicol resistant and chloramphenicol sensitive typhoid fever

Robert H Gilman, M. Terminel, M. M. Levine, P. Hernandez-Mendosa, E. Calderone, V. Vasquez, E. Martinez, M. J. Snyder, R. B. Hornick

Research output: Contribution to journalArticle

Abstract

The efficacy of orally administered trimethoprim sulfamethoxazole was compared with that of oral amoxicillin in therapy of typhoid fever due to both epidemic chloramphenicol resistant and endemic chloramphenicol sensitive Salmonella typhi. Both drug regimens were effective and of comparable value in treatment of chloramphenicol resistant infections, as measured by duration of fever (124 hr and 115 hr, respectively) and duration of bacteremia (1.0 and 0.4 days, respectively). Trimethoprim sulfamethoxazole therapy of infections due to chloramphenicol sensitive S. typhi resulted in more rapid lysis of fever than did amoxicillin therapy. Trimethoprim and sulfamethoxazole were not synergistic in vitro against the chloramphenicol resistant strain of S. typhi, and the role of sulfamethoxazole in treatment of such infections appears to be minimal. Oral administration of trimethoprim sulfamethoxazole is effective therapy of chloramphenicol resistant, and probably of ampicillin amoxicillin resistant, typhoid fever.

Original languageEnglish (US)
Pages (from-to)630-636
Number of pages7
JournalJournal of Investigative Dermatology
Volume132
Issue number6
StatePublished - 1975
Externally publishedYes

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Typhoid Fever
Amoxicillin
Sulfamethoxazole Drug Combination Trimethoprim
Chloramphenicol
Salmonella typhi
Therapeutics
Infection
Sulfamethoxazole
Induced Hyperthermia
Salmonella
Ampicillin
Bacteremia
Oral Administration
Fever
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dermatology

Cite this

Gilman, R. H., Terminel, M., Levine, M. M., Hernandez-Mendosa, P., Calderone, E., Vasquez, V., ... Hornick, R. B. (1975). Comparison of trimethoprim sulfamethoxazole and amoxicillin in therapy of chloramphenicol resistant and chloramphenicol sensitive typhoid fever. Journal of Investigative Dermatology, 132(6), 630-636.

Comparison of trimethoprim sulfamethoxazole and amoxicillin in therapy of chloramphenicol resistant and chloramphenicol sensitive typhoid fever. / Gilman, Robert H; Terminel, M.; Levine, M. M.; Hernandez-Mendosa, P.; Calderone, E.; Vasquez, V.; Martinez, E.; Snyder, M. J.; Hornick, R. B.

In: Journal of Investigative Dermatology, Vol. 132, No. 6, 1975, p. 630-636.

Research output: Contribution to journalArticle

Gilman, RH, Terminel, M, Levine, MM, Hernandez-Mendosa, P, Calderone, E, Vasquez, V, Martinez, E, Snyder, MJ & Hornick, RB 1975, 'Comparison of trimethoprim sulfamethoxazole and amoxicillin in therapy of chloramphenicol resistant and chloramphenicol sensitive typhoid fever', Journal of Investigative Dermatology, vol. 132, no. 6, pp. 630-636.
Gilman, Robert H ; Terminel, M. ; Levine, M. M. ; Hernandez-Mendosa, P. ; Calderone, E. ; Vasquez, V. ; Martinez, E. ; Snyder, M. J. ; Hornick, R. B. / Comparison of trimethoprim sulfamethoxazole and amoxicillin in therapy of chloramphenicol resistant and chloramphenicol sensitive typhoid fever. In: Journal of Investigative Dermatology. 1975 ; Vol. 132, No. 6. pp. 630-636.
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