Comparison of time of reperfusion during anterior wall acute myocardial infarction to left ventricular volume one month and 20 months later

Atsushi Hirayama, Hideo Kusuoka, Takayoshi Adachi, Akihiko Sakai, Yasunori Ueda, Yuji Okuyama, Hisakazu Fuji, Yasuhiko Sakata, Yasushi Sakata, Masanori Asakura, Hiroyoshi Yamamoto, Yasuharu Higuchi, Masatusugu Hori, Kazuhisa Kodama

Research output: Contribution to journalArticlepeer-review

Abstract

We studied 95 patients with a first anterior wall acute myocardial infarction who received successful reperfusion within 72 hours after the onset. The patients were divided into 4 groups based on the time required to achieve reperfusion; <3 hours (n = 23), 3 to 6 hours (n = 42), 6 to 24 hours (n = 17), and >24 to 72 hours (n = 13). The infarct size, as evaluated by thallium-201 single-photon emission computed tomography, at 1 month after the infarct was significantly larger (p <0.05) in >24 to 72 hours (1,593 ± 652 U) than that in <3 hours (749 ± 650 U), but was not significantly different from that at 3 to 6 hours (1,353 ± 770 U) or 6 to 24 hours (1,371 ± 561 U). The end-diastolic volume index at 1 month did not differ among the 4 groups. However, the end-diastolic volume index during the follow-up period (20 ± 8 months) in >24 to 72 hours (93 ± 23 ml/m2) was significantly larger than that in the other 3 groups (<3 hours [65 ± 21 ml/m2], 3 to 6 hours [65 ± 22 ml/m2], and 6 to 24 hours [70 ± 25 ml/m2]). Similar findings were observed in end-systolic volume index. In conclusion, although infarct size reduction was not observed by late reperfusion, left ventricular volumes at 1 month were comparable among patients with successful reperfusion within 3 and up to >24 hours. Left ventricular volumes 2 years after acute myocardial infarction were significantly larger in patients who did not under reperfusion for >24 hours.

Original languageEnglish (US)
Pages (from-to)1335-1340
Number of pages6
JournalAmerican Journal of Cardiology
Volume89
Issue number12
DOIs
StatePublished - Jun 15 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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