TY - JOUR
T1 - Comparison of three societally derived health-state classification values among older African Americans with depressive symptoms
AU - Jutkowitz, Eric
AU - Pizzi, Laura
AU - Hess, Edward
AU - Suh, Dong Churl
AU - Gitlin, Laura N.
N1 - Funding Information:
Funding Funded by the National Institute of Mental Health grants #RO1 MH 079814, R24 MH074779 and RC1MH090770. Clinical trial registration #: NCT00511680.
PY - 2013/8
Y1 - 2013/8
N2 - Purpose: To compare societal values across three health-state classification systems in older African Americans with depression and to describe the association of these instruments to depression severity. Methods: We summarized baseline values for EQ-5D (US weights) and HUI2/3 (Canadian weights) and their subscales for 118 older African American participants enrolled in a randomized depression treatment trial and calculated correlations between the different instruments. We evaluated ceiling and floor effects for each instrument by comparing the proportion at the highest and lowest possible score for each tool. Also, utility scores were assessed by level of depression severity (mild, moderate, moderate severe, severe) scores as measured by the Patient Health Questionnaire (PHQ-9). Results: Mean utility values were 0.58 (SD = 0.21) for EQ-5D, 0.52 (SD = 0.21) for HUI2, and 0.36 (SD = 0.31) for HUI3. For the EQ-5D, 72 % of participants reported having some problems on the anxiety/depression domain. On the emotion domain for the HUI2, 23 % reported the highest level of impairment compared to only 3 % on the HUI3. No participant scored at the floor for the EQ-5D, HUI2, or HUI3 index; one participant scored at the ceiling value on the HUI3 index. Correlations ranged from 0.63 to 0.82 (all of which were significant at an alpha level of 0.05). In general, utility scores trended inversely with depression level. Conclusion: Small differences in the three preference-weighted health-state classification systems were evident for this sample of older African Americans with depressive symptoms, with HUI scores lower than EQ-5D. For this sample, utility scores were lower (i.e.; poorer) than the general United States population with depression on each utility measure.
AB - Purpose: To compare societal values across three health-state classification systems in older African Americans with depression and to describe the association of these instruments to depression severity. Methods: We summarized baseline values for EQ-5D (US weights) and HUI2/3 (Canadian weights) and their subscales for 118 older African American participants enrolled in a randomized depression treatment trial and calculated correlations between the different instruments. We evaluated ceiling and floor effects for each instrument by comparing the proportion at the highest and lowest possible score for each tool. Also, utility scores were assessed by level of depression severity (mild, moderate, moderate severe, severe) scores as measured by the Patient Health Questionnaire (PHQ-9). Results: Mean utility values were 0.58 (SD = 0.21) for EQ-5D, 0.52 (SD = 0.21) for HUI2, and 0.36 (SD = 0.31) for HUI3. For the EQ-5D, 72 % of participants reported having some problems on the anxiety/depression domain. On the emotion domain for the HUI2, 23 % reported the highest level of impairment compared to only 3 % on the HUI3. No participant scored at the floor for the EQ-5D, HUI2, or HUI3 index; one participant scored at the ceiling value on the HUI3 index. Correlations ranged from 0.63 to 0.82 (all of which were significant at an alpha level of 0.05). In general, utility scores trended inversely with depression level. Conclusion: Small differences in the three preference-weighted health-state classification systems were evident for this sample of older African Americans with depressive symptoms, with HUI scores lower than EQ-5D. For this sample, utility scores were lower (i.e.; poorer) than the general United States population with depression on each utility measure.
KW - Cost-effectiveness analysis
KW - EQ-5D
KW - HUI3
KW - Quality of life
KW - Utility
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U2 - 10.1007/s11136-012-0263-y
DO - 10.1007/s11136-012-0263-y
M3 - Article
C2 - 22972437
AN - SCOPUS:84885187739
SN - 0962-9343
VL - 22
SP - 1491
EP - 1498
JO - Quality of Life Research
JF - Quality of Life Research
IS - 6
ER -