Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves

Charlotte S D Stahl, Serhat Tozburun, Thomas C. Hutchens, Gwen A. Lagoda, Arthur Burnett, Matthew D. Keller, Nathaniel M. Fried

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Optical nerve stimulation (ONS) is being explored for identification and preservation of the cavernous nerves (CN), responsible for erectile function, during prostate cancer surgery. This study compares three pulsed infrared lasers to determine whether differences in spectral linewidth and/or temporal pulse profile influence successful ONS of CN. Infrared laser radiation from the Capella diode laser (1873 nm, 5 ms, 10 Hz), Thulium fiber laser (TFL) (1873 nm, 5 ms, 10 Hz), and solid-state Holmium:YAG laser (2120 nm, 200 μs, 5 Hz) were transmitted through 400-μm-corediameter optical fibers, producing a 1-mm-diameter-spot on the nerve surface. Successful ONS was judged by an intracavernous pressure (ICP) response in the penis (n =10 rats) during a total stimulation time of 30 s. The narrow linewidth TFL (Δλ ∼ 0.5 nm) and broad linewidth Capella laser (Δλ ∼ 12 nm) performed similarly, producing ICP responses with a threshold radiant exposure of ∼ 0.45 J/cm2, and ICP response times of 12-17 s, while the Holmium laser stimulated at ∼ 0.59 J/cm2, and ICP response times of about 14-28 s. All three lasers demonstrated successful ONS of CN. ICP response time was dependent on the rate of energy deposition into the CN, rather than linewidth or temporal pulse profile.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8565
DOIs
StatePublished - 2013
EventPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
Duration: Feb 2 2013Feb 7 2013

Other

OtherPhotonic Therapeutics and Diagnostics IX
CountryUnited States
CitySan Francisco, CA
Period2/2/132/7/13

Fingerprint

Infrared lasers
nerves
Pulsed lasers
stimulation
infrared lasers
rats
Rats
Prostate
pulsed lasers
Lasers
Linewidth
Thulium
Holmium
Solid-State Lasers
Pressure
Reaction Time
Fiber lasers
thulium
holmium
Optical Fibers

Keywords

  • Cavernous nerves
  • Infrared lasers
  • Optical nerve stimulation
  • Prostate

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Stahl, C. S. D., Tozburun, S., Hutchens, T. C., Lagoda, G. A., Burnett, A., Keller, M. D., & Fried, N. M. (2013). Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8565). [85655N] https://doi.org/10.1117/12.2000537

Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves. / Stahl, Charlotte S D; Tozburun, Serhat; Hutchens, Thomas C.; Lagoda, Gwen A.; Burnett, Arthur; Keller, Matthew D.; Fried, Nathaniel M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565 2013. 85655N.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stahl, CSD, Tozburun, S, Hutchens, TC, Lagoda, GA, Burnett, A, Keller, MD & Fried, NM 2013, Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8565, 85655N, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2000537
Stahl CSD, Tozburun S, Hutchens TC, Lagoda GA, Burnett A, Keller MD et al. Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565. 2013. 85655N https://doi.org/10.1117/12.2000537
Stahl, Charlotte S D ; Tozburun, Serhat ; Hutchens, Thomas C. ; Lagoda, Gwen A. ; Burnett, Arthur ; Keller, Matthew D. ; Fried, Nathaniel M. / Comparison of three pulsed infrared lasers for optical stimulation of the rat prostate cavernous nerves. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565 2013.
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