Comparison of three computer-administered cognitive tasks as putative endophenotypes of schizophrenia

Jeffrey S. Bedwell, Vidyulata Kamath, Elizabeth Baksh

Research output: Contribution to journalArticle

Abstract

It has been repeatedly demonstrated that individuals with schizotypal personality features (SPF) exhibit similar endophenotypic traits as persons with schizophrenia. Less research has compared the relative sensitivity of different endophenotypes in the same sample of individuals with SPF. Fourteen university students with SPF (mean age 20.5 ± 1.6; 43% male) and 26 controls (mean age 20.3 ± 1.1; 31% male) were defined by the Abbreviated Schizotypal Personality Questionnaire (SPQ-B). All participants reported no known biological relative with schizophrenia. Participants completed three computer-administered cognitive tasks: a 6-min degraded-stimuli A-X Continuous Performance Test (CPT), the Wisconsin Card Sort Test (WCST), and a Span of Apprehension (SOA) task (6- and 12-letter arrays). On the CPT, only omission errors resulted in a statistically significant group difference, U = 115.5, p = .05, Cohen's d = 0.54 (medium effect size), with the SPF group (mean errors: 3.43 ± 3.28) making more omission errors than controls (mean errors: 1.88 ± 2.66). Notably, 46% of the controls had no omission errors, compared to 14% of the SPF group. The only SPQ-B factor score to show a statistically significant linear relationship with CPT omission errors was the Cognitive-Perceptual factor (rs = .33, p = .04). Group differences on performance indices from the SOA and WCST did not approach statistical significance. Based on performance from the community-identified schizotypes, results suggest that performance on the CPT may represent a more robust endophenotype of schizophrenia, compared to the SOA and WCST.

Original languageEnglish (US)
Pages (from-to)36-46
Number of pages11
JournalSchizophrenia Research
Volume88
Issue number1-3
DOIs
StatePublished - Dec 2006
Externally publishedYes

Fingerprint

Endophenotypes
Personality
Schizophrenia
Students
Research

Keywords

  • Continuous Performance Test
  • Endophenotypes
  • Schizophrenia
  • Schizotypal personality questionnaire
  • Schizotypy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Comparison of three computer-administered cognitive tasks as putative endophenotypes of schizophrenia. / Bedwell, Jeffrey S.; Kamath, Vidyulata; Baksh, Elizabeth.

In: Schizophrenia Research, Vol. 88, No. 1-3, 12.2006, p. 36-46.

Research output: Contribution to journalArticle

@article{4301d3bc4f1340a9bedfa8fb842e60fd,
title = "Comparison of three computer-administered cognitive tasks as putative endophenotypes of schizophrenia",
abstract = "It has been repeatedly demonstrated that individuals with schizotypal personality features (SPF) exhibit similar endophenotypic traits as persons with schizophrenia. Less research has compared the relative sensitivity of different endophenotypes in the same sample of individuals with SPF. Fourteen university students with SPF (mean age 20.5 ± 1.6; 43{\%} male) and 26 controls (mean age 20.3 ± 1.1; 31{\%} male) were defined by the Abbreviated Schizotypal Personality Questionnaire (SPQ-B). All participants reported no known biological relative with schizophrenia. Participants completed three computer-administered cognitive tasks: a 6-min degraded-stimuli A-X Continuous Performance Test (CPT), the Wisconsin Card Sort Test (WCST), and a Span of Apprehension (SOA) task (6- and 12-letter arrays). On the CPT, only omission errors resulted in a statistically significant group difference, U = 115.5, p = .05, Cohen's d = 0.54 (medium effect size), with the SPF group (mean errors: 3.43 ± 3.28) making more omission errors than controls (mean errors: 1.88 ± 2.66). Notably, 46{\%} of the controls had no omission errors, compared to 14{\%} of the SPF group. The only SPQ-B factor score to show a statistically significant linear relationship with CPT omission errors was the Cognitive-Perceptual factor (rs = .33, p = .04). Group differences on performance indices from the SOA and WCST did not approach statistical significance. Based on performance from the community-identified schizotypes, results suggest that performance on the CPT may represent a more robust endophenotype of schizophrenia, compared to the SOA and WCST.",
keywords = "Continuous Performance Test, Endophenotypes, Schizophrenia, Schizotypal personality questionnaire, Schizotypy",
author = "Bedwell, {Jeffrey S.} and Vidyulata Kamath and Elizabeth Baksh",
year = "2006",
month = "12",
doi = "10.1016/j.schres.2006.08.002",
language = "English (US)",
volume = "88",
pages = "36--46",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Comparison of three computer-administered cognitive tasks as putative endophenotypes of schizophrenia

AU - Bedwell, Jeffrey S.

AU - Kamath, Vidyulata

AU - Baksh, Elizabeth

PY - 2006/12

Y1 - 2006/12

N2 - It has been repeatedly demonstrated that individuals with schizotypal personality features (SPF) exhibit similar endophenotypic traits as persons with schizophrenia. Less research has compared the relative sensitivity of different endophenotypes in the same sample of individuals with SPF. Fourteen university students with SPF (mean age 20.5 ± 1.6; 43% male) and 26 controls (mean age 20.3 ± 1.1; 31% male) were defined by the Abbreviated Schizotypal Personality Questionnaire (SPQ-B). All participants reported no known biological relative with schizophrenia. Participants completed three computer-administered cognitive tasks: a 6-min degraded-stimuli A-X Continuous Performance Test (CPT), the Wisconsin Card Sort Test (WCST), and a Span of Apprehension (SOA) task (6- and 12-letter arrays). On the CPT, only omission errors resulted in a statistically significant group difference, U = 115.5, p = .05, Cohen's d = 0.54 (medium effect size), with the SPF group (mean errors: 3.43 ± 3.28) making more omission errors than controls (mean errors: 1.88 ± 2.66). Notably, 46% of the controls had no omission errors, compared to 14% of the SPF group. The only SPQ-B factor score to show a statistically significant linear relationship with CPT omission errors was the Cognitive-Perceptual factor (rs = .33, p = .04). Group differences on performance indices from the SOA and WCST did not approach statistical significance. Based on performance from the community-identified schizotypes, results suggest that performance on the CPT may represent a more robust endophenotype of schizophrenia, compared to the SOA and WCST.

AB - It has been repeatedly demonstrated that individuals with schizotypal personality features (SPF) exhibit similar endophenotypic traits as persons with schizophrenia. Less research has compared the relative sensitivity of different endophenotypes in the same sample of individuals with SPF. Fourteen university students with SPF (mean age 20.5 ± 1.6; 43% male) and 26 controls (mean age 20.3 ± 1.1; 31% male) were defined by the Abbreviated Schizotypal Personality Questionnaire (SPQ-B). All participants reported no known biological relative with schizophrenia. Participants completed three computer-administered cognitive tasks: a 6-min degraded-stimuli A-X Continuous Performance Test (CPT), the Wisconsin Card Sort Test (WCST), and a Span of Apprehension (SOA) task (6- and 12-letter arrays). On the CPT, only omission errors resulted in a statistically significant group difference, U = 115.5, p = .05, Cohen's d = 0.54 (medium effect size), with the SPF group (mean errors: 3.43 ± 3.28) making more omission errors than controls (mean errors: 1.88 ± 2.66). Notably, 46% of the controls had no omission errors, compared to 14% of the SPF group. The only SPQ-B factor score to show a statistically significant linear relationship with CPT omission errors was the Cognitive-Perceptual factor (rs = .33, p = .04). Group differences on performance indices from the SOA and WCST did not approach statistical significance. Based on performance from the community-identified schizotypes, results suggest that performance on the CPT may represent a more robust endophenotype of schizophrenia, compared to the SOA and WCST.

KW - Continuous Performance Test

KW - Endophenotypes

KW - Schizophrenia

KW - Schizotypal personality questionnaire

KW - Schizotypy

UR - http://www.scopus.com/inward/record.url?scp=33750634177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750634177&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2006.08.002

DO - 10.1016/j.schres.2006.08.002

M3 - Article

VL - 88

SP - 36

EP - 46

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -