TY - JOUR
T1 - Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma
AU - Mu, Euphemia
AU - Lange, Julie R.
AU - Strouse, John J.
PY - 2012/5/15
Y1 - 2012/5/15
N2 - BACKGROUND: Data on sentinel lymph node (SLN) biopsy in children with melanoma are limited. In this study, the authors compared the factors associated with SLN biopsy use and metastases in pediatric and young adult patients with melanoma. METHODS: The 2008 Surveillance, Epidemiology, and End Results (SEER) databases were used to examine melanoma cases from 2003 to 2008. Data extracted include age, sex, race, stage, tumor thickness, ulceration, lymph node status, surgical treatment, and survival. Logistic regression models were used for adjusted analyses. RESULTS: In total, 717 children (age <20 years) and 1368 young adults (age 20-24 years) were identified who were diagnosed with melanoma. Factors that were associated with SLN biopsy use included tumor ulceration (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.4-4.3) and greater thickness (OR, 17; 95% CI, 12-24 for >1 mm vs ≤1 mm), but not younger age (OR, 1.3; 95% CI, 0.94-1.8) in adjusted analyses. SLN metastasis was correlated with ulceration (OR, 3.0; 95% CI, 1.6-5.8), increased thickness (OR, 6.8; 95% CI, 3.1-15 for 2.01-4.0 mm vs a;circ1 mm), and for the interaction between age <20 years and thickness 1.01 to 2.00 mm (OR, 6.5; 95% CI, 1.7-25) in adjusted analyses. Children with nonulcerated melanomas that measured 1.01 to 2.00 mm in thickness were significantly more likely to have SLN metastases than young adults (24% vs 4%; P <.001). CONCLUSIONS: Thickness and ulceration were strong predictors of both the use of SLN biopsy and positive SLN biopsy results in children and young adults with melanoma. Compared with young adults, children were more likely to have SLN metastases despite having similar rates of SLN biopsy use. Cancer 2011;. © 2011 American Cancer Society. The results from this study indicate that thickness and ulceration are strong predictors of sentinel lymph node (SLN) biopsy use and SLN metastases in pediatric and young adult patients with melanoma. Children and young adults have similar rates of SLN biopsy use, but children are more likely to have SLN metastases.
AB - BACKGROUND: Data on sentinel lymph node (SLN) biopsy in children with melanoma are limited. In this study, the authors compared the factors associated with SLN biopsy use and metastases in pediatric and young adult patients with melanoma. METHODS: The 2008 Surveillance, Epidemiology, and End Results (SEER) databases were used to examine melanoma cases from 2003 to 2008. Data extracted include age, sex, race, stage, tumor thickness, ulceration, lymph node status, surgical treatment, and survival. Logistic regression models were used for adjusted analyses. RESULTS: In total, 717 children (age <20 years) and 1368 young adults (age 20-24 years) were identified who were diagnosed with melanoma. Factors that were associated with SLN biopsy use included tumor ulceration (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.4-4.3) and greater thickness (OR, 17; 95% CI, 12-24 for >1 mm vs ≤1 mm), but not younger age (OR, 1.3; 95% CI, 0.94-1.8) in adjusted analyses. SLN metastasis was correlated with ulceration (OR, 3.0; 95% CI, 1.6-5.8), increased thickness (OR, 6.8; 95% CI, 3.1-15 for 2.01-4.0 mm vs a;circ1 mm), and for the interaction between age <20 years and thickness 1.01 to 2.00 mm (OR, 6.5; 95% CI, 1.7-25) in adjusted analyses. Children with nonulcerated melanomas that measured 1.01 to 2.00 mm in thickness were significantly more likely to have SLN metastases than young adults (24% vs 4%; P <.001). CONCLUSIONS: Thickness and ulceration were strong predictors of both the use of SLN biopsy and positive SLN biopsy results in children and young adults with melanoma. Compared with young adults, children were more likely to have SLN metastases despite having similar rates of SLN biopsy use. Cancer 2011;. © 2011 American Cancer Society. The results from this study indicate that thickness and ulceration are strong predictors of sentinel lymph node (SLN) biopsy use and SLN metastases in pediatric and young adult patients with melanoma. Children and young adults have similar rates of SLN biopsy use, but children are more likely to have SLN metastases.
KW - diagnostic
KW - melanoma
KW - pediatric
KW - sentinel lymph node biopsy
KW - young adult
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U2 - 10.1002/cncr.26578
DO - 10.1002/cncr.26578
M3 - Article
C2 - 22565612
AN - SCOPUS:84860692840
VL - 118
SP - 2700
EP - 2707
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 10
ER -