Comparison of the thrombogenicity of stainless steel and tantalum coronary stents

Neal A. Scott; Keith A. Robinson; Gilberto L. Nunes; Clifford N. Thomas; Kevin Viel; Spencer B. King; Laurence A. Harker; Steven M. Rowland; Ike Juman; Gustavo D. Cipolla; Stephenson R. Hanson

doi:10.1016/0002-8703(95)90105-1

Comparison of the thrombogenicity of stainless steel and tantalum coronary stents

Neal A. Scott, Keith A. Robinson, Gilberto L. Nunes, Clifford N. Thomas, Kevin Viel, Spencer B. King, Laurence A. Harker, Steven M. Rowland, Ike Juman, Gustavo D. Cipolla, Stephenson R. Hanson

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

This study was designed to compare the thrombogenicity of stainless steel and tantalum coronary stents of the same design. Stainless steel and tantalum coronary stents are being evaluated for their utility in treating acute closure and restenosis. A major disadvantage of stainless steel stents is radiolucency. To determine whether radioopaque tantalum stents may be safely substituted for stainless steel stents, we compared the relative thrombogenicity of these materials in stents of identical design. Total platelet and fibrin deposition on the stents were determined from measurements of indium 111-labeled platelet and iodine 125-labeled fibrinogen accumulation after deployment into exteriorized chronic arteriovenous shunts in seven untreated baboons. In another series of experiments, ¹¹¹In-platelet deposition was compared 2 hours after stent implantation in coronary arteries of pigs. In baboons, platelet thrombus formation on stainless steel and tantalum stents was equivalent and plateaued at approximately 2.5 × 10⁹ platelets after 1 hour (p > 0.05). Fibrin deposition averaged approximately 1 mg/stent and did not differ between the stainless steel and tantalum stents (p . 0.05). In the porcine coronary model there was no significant difference in ¹¹¹In-labeled platelet deposition between the stainless steel and tantalum stents (p > 0.05). This result was confirmed by scanning electron microscopic analysis of the coronary stents. Based on these two models, we conclude that there is no significant difference in the thrombogenicity of stainless steel and tantalum wire coil stents.

Original language	English (US)
Pages (from-to)	866-872
Number of pages	7
Journal	American heart journal
Volume	129
Issue number	5
DOIs	https://doi.org/10.1016/0002-8703(95)90105-1
State	Published - May 1995
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0002-8703(95)90105-1

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@article{951ba92f3dec421fa88696114d09d3e9,

title = "Comparison of the thrombogenicity of stainless steel and tantalum coronary stents",

abstract = "This study was designed to compare the thrombogenicity of stainless steel and tantalum coronary stents of the same design. Stainless steel and tantalum coronary stents are being evaluated for their utility in treating acute closure and restenosis. A major disadvantage of stainless steel stents is radiolucency. To determine whether radioopaque tantalum stents may be safely substituted for stainless steel stents, we compared the relative thrombogenicity of these materials in stents of identical design. Total platelet and fibrin deposition on the stents were determined from measurements of indium 111-labeled platelet and iodine 125-labeled fibrinogen accumulation after deployment into exteriorized chronic arteriovenous shunts in seven untreated baboons. In another series of experiments, 111In-platelet deposition was compared 2 hours after stent implantation in coronary arteries of pigs. In baboons, platelet thrombus formation on stainless steel and tantalum stents was equivalent and plateaued at approximately 2.5 × 109 platelets after 1 hour (p > 0.05). Fibrin deposition averaged approximately 1 mg/stent and did not differ between the stainless steel and tantalum stents (p . 0.05). In the porcine coronary model there was no significant difference in 111In-labeled platelet deposition between the stainless steel and tantalum stents (p > 0.05). This result was confirmed by scanning electron microscopic analysis of the coronary stents. Based on these two models, we conclude that there is no significant difference in the thrombogenicity of stainless steel and tantalum wire coil stents.",

author = "Scott, {Neal A.} and Robinson, {Keith A.} and Nunes, {Gilberto L.} and Thomas, {Clifford N.} and Kevin Viel and King, {Spencer B.} and Harker, {Laurence A.} and Rowland, {Steven M.} and Ike Juman and Cipolla, {Gustavo D.} and Hanson, {Stephenson R.}",

note = "Funding Information: From the aAndreas Gruentzig Cardiovascular Center, Emory University Hospital, and the bDivision of Hematology and Oncology, Emory University School of Medicine, Atlanta, and the CCordis Corporation, Miami. Dr. Scott is a fellow of the Robert Wood Johnson Foundation for Minority Faculty Development. This work was supported by research grants HL41619 and HL31469 from the National Institutes of Health and part by National Institutes of Health grant RR-00165, awarded to the Yerkes Regional Primate Center, which is fully accredited by the American Association for Accreditation of Laboratory Animal Care. Received for publication Nov. 17, 1993; accepted Aug. 15, 1994. Reprint requests: Neal A. Scott, MD, PhD, Andreas Gruentzig Cardiovascular Center, Emory University Hospital, Suite F-606, 1364 Clifton Rd., Atlanta, GA 30322. Copyright {\textcopyright} 1995 by Mosby-Year Book, Inc. 0002-8703/95/$3.00 + 0 4/1/61641",

year = "1995",

month = may,

doi = "10.1016/0002-8703(95)90105-1",

language = "English (US)",

volume = "129",

pages = "866--872",

journal = "American heart journal",

issn = "0002-8703",

publisher = "Mosby Inc.",

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T1 - Comparison of the thrombogenicity of stainless steel and tantalum coronary stents

AU - Scott, Neal A.

AU - Robinson, Keith A.

AU - Nunes, Gilberto L.

AU - Thomas, Clifford N.

AU - Viel, Kevin

AU - King, Spencer B.

AU - Harker, Laurence A.

AU - Rowland, Steven M.

AU - Juman, Ike

AU - Cipolla, Gustavo D.

AU - Hanson, Stephenson R.

N1 - Funding Information: From the aAndreas Gruentzig Cardiovascular Center, Emory University Hospital, and the bDivision of Hematology and Oncology, Emory University School of Medicine, Atlanta, and the CCordis Corporation, Miami. Dr. Scott is a fellow of the Robert Wood Johnson Foundation for Minority Faculty Development. This work was supported by research grants HL41619 and HL31469 from the National Institutes of Health and part by National Institutes of Health grant RR-00165, awarded to the Yerkes Regional Primate Center, which is fully accredited by the American Association for Accreditation of Laboratory Animal Care. Received for publication Nov. 17, 1993; accepted Aug. 15, 1994. Reprint requests: Neal A. Scott, MD, PhD, Andreas Gruentzig Cardiovascular Center, Emory University Hospital, Suite F-606, 1364 Clifton Rd., Atlanta, GA 30322. Copyright © 1995 by Mosby-Year Book, Inc. 0002-8703/95/$3.00 + 0 4/1/61641

PY - 1995/5

Y1 - 1995/5

N2 - This study was designed to compare the thrombogenicity of stainless steel and tantalum coronary stents of the same design. Stainless steel and tantalum coronary stents are being evaluated for their utility in treating acute closure and restenosis. A major disadvantage of stainless steel stents is radiolucency. To determine whether radioopaque tantalum stents may be safely substituted for stainless steel stents, we compared the relative thrombogenicity of these materials in stents of identical design. Total platelet and fibrin deposition on the stents were determined from measurements of indium 111-labeled platelet and iodine 125-labeled fibrinogen accumulation after deployment into exteriorized chronic arteriovenous shunts in seven untreated baboons. In another series of experiments, 111In-platelet deposition was compared 2 hours after stent implantation in coronary arteries of pigs. In baboons, platelet thrombus formation on stainless steel and tantalum stents was equivalent and plateaued at approximately 2.5 × 109 platelets after 1 hour (p > 0.05). Fibrin deposition averaged approximately 1 mg/stent and did not differ between the stainless steel and tantalum stents (p . 0.05). In the porcine coronary model there was no significant difference in 111In-labeled platelet deposition between the stainless steel and tantalum stents (p > 0.05). This result was confirmed by scanning electron microscopic analysis of the coronary stents. Based on these two models, we conclude that there is no significant difference in the thrombogenicity of stainless steel and tantalum wire coil stents.

AB - This study was designed to compare the thrombogenicity of stainless steel and tantalum coronary stents of the same design. Stainless steel and tantalum coronary stents are being evaluated for their utility in treating acute closure and restenosis. A major disadvantage of stainless steel stents is radiolucency. To determine whether radioopaque tantalum stents may be safely substituted for stainless steel stents, we compared the relative thrombogenicity of these materials in stents of identical design. Total platelet and fibrin deposition on the stents were determined from measurements of indium 111-labeled platelet and iodine 125-labeled fibrinogen accumulation after deployment into exteriorized chronic arteriovenous shunts in seven untreated baboons. In another series of experiments, 111In-platelet deposition was compared 2 hours after stent implantation in coronary arteries of pigs. In baboons, platelet thrombus formation on stainless steel and tantalum stents was equivalent and plateaued at approximately 2.5 × 109 platelets after 1 hour (p > 0.05). Fibrin deposition averaged approximately 1 mg/stent and did not differ between the stainless steel and tantalum stents (p . 0.05). In the porcine coronary model there was no significant difference in 111In-labeled platelet deposition between the stainless steel and tantalum stents (p > 0.05). This result was confirmed by scanning electron microscopic analysis of the coronary stents. Based on these two models, we conclude that there is no significant difference in the thrombogenicity of stainless steel and tantalum wire coil stents.

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Comparison of the thrombogenicity of stainless steel and tantalum coronary stents

Abstract

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