Comparison of the prognostic utility of the revised International Prognostic Scoring System and the French Prognostic Scoring System in azacitidine-treated patients with myelodysplastic syndromes

Amer M. Zeidan, Ju Whei Lee, Thomas Prebet, Peter Greenberg, Zhuoxin Sun, Mark Juckett, Mitchell R. Smith, Elisabeth Paietta, Janice Gabrilove, Harry P. Erba, Martin S. Tallman, Steven D. Gore

Research output: Contribution to journalArticle

Abstract

Summary: The revised International Prognostic Scoring System (IPSS-R) was developed in a cohort of untreated myelodysplastic syndromes (MDS) patients. A French Prognostic Scoring System (FPSS) was recently reported to identify differential survival among azacitidine-treated patients with high-risk MDS. We applied the FPSS and IPSS-R to 150 patients previously randomized to azacitidine monotherapy or a combination of azacitidine with entinostat (a histone deacetylase inhibitor). Neither score predicted response but both discriminated patients with different overall survival (OS; median OS, FPSS: 9·7, 14·7, and 25·3 months, P = 0·018; IPSS-R: 12·5, 11·3, 20·8, and 36 months, P = 0·005). Statistical analysis suggested no improvement in OS prediction for the FPSS over the IPSS-R in azacitidine-treated patients.

Original languageEnglish (US)
Pages (from-to)352-359
Number of pages8
JournalBritish journal of haematology
Volume166
Issue number3
DOIs
StatePublished - Aug 2014

Keywords

  • Azacitidine
  • French Prognostic Scoring System
  • Myelodysplastic syndromes
  • Prognostic models
  • Revised International Prognostic Scoring System

ASJC Scopus subject areas

  • Hematology

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    Zeidan, A. M., Lee, J. W., Prebet, T., Greenberg, P., Sun, Z., Juckett, M., Smith, M. R., Paietta, E., Gabrilove, J., Erba, H. P., Tallman, M. S., & Gore, S. D. (2014). Comparison of the prognostic utility of the revised International Prognostic Scoring System and the French Prognostic Scoring System in azacitidine-treated patients with myelodysplastic syndromes. British journal of haematology, 166(3), 352-359. https://doi.org/10.1111/bjh.12884