Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between wistar kyoto and sprague dawley rats

Gregory V. Carr, I. Lucki

Research output: Contribution to journalArticlepeer-review

Abstract

Rationale Recent, evidence suggests a role for the dynorphin/ kappa-opioid receptor (KOR) system in the expression of stress-induced behaviors. Wistar Kyoto (WKY) rats exhibit increased depression-like and anxiety-like responses in behavioral tests compared to other strains and may be a model of comorbid depression and anxiety characterized by increased activity within the dynorphin/KOR system. Though KOR antagonists produce antidepressant-like effects in WKY rats, their effects in tests of anxiety-like behavior have not been examined in the WKY strain. Objective The aim of the current study was to investigate the effects of the KOR antagonist 2-(3,4-dichlorophenyl)-Nmethyl-N- [(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl) ethyl] acetamide hydrochloride (DIPPA) on the behavior of WKY rats and Sprague Dawley (SD) rats in tests of anxietylike behavior. Methods The novelty-induced hypophagia and defensive burying tests were used to measure anxiety-like behavior in WKY and SD rats and determine the effects of DIPPA on anxiety-like behavior in both strains. Results WKY rats displayed greater amounts of anxietylike behavior compared to SD rats. DIPPA produced anxiolytic-like effects in both tests in both strains. Conclusions WKY rats display more anxiety-like behavior at baseline compared to SD rats, and DIPPA produced anxiolytic-like effects in both WKY and SD rats. These findings support previous research suggesting that. KOR antagonists possess anxiolytic-like properties and may potentially represent a novel class of treatments for mood disorders.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalPsychopharmacology
Volume210
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Anxiety
  • Defensive burying
  • Kappa-opioid receptor
  • Novelty-induced hypophagia
  • Wistar kyoto rat

ASJC Scopus subject areas

  • Pharmacology

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