Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: Scald injury versus I.P. LPS administration

Christian R. Gomez, Vanessa Nomellini, Horea Baila, Kiyoko Oshima, Elizabeth J. Kovacs

Research output: Contribution to journalArticlepeer-review

Abstract

Regardless of age, a marked elevation in circulating IL-6 levels correlates with increased mortality after injury or an inflammatory challenge. We previously reported that aged IL-6 knockout mice given LPS have improved survival and reduced inflammatory response than LPS-treated aged wild type (WT) mice. Herein, we analyzed the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: dorsal scald (burn) injury versus intraperitoneal LPS administration. At 24 h after burn injury, circulating alanine aminotransferase and hepatic neutrophil accumulation were comparable regardless of age or IL-6 deficiency. However, at this same time point, these indicators of liver damage, in addition to hepatic levels of KC, a neutrophil chemoattractant, were increased in aged WT mice given LPS relative to young WT mice given LPS. The hepatic injury was drastically reduced in aged IL-6 knockout mice given LPS as compared with LPS-exposed aged WT mice. Our results suggest that the nature of the insult will determine the degree of remote injury in aged animals. In addition, the role of IL-6 as a contributing factor of tissue injury may be insult specific.

Original languageEnglish (US)
Pages (from-to)178-184
Number of pages7
JournalShock
Volume31
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • ALT
  • Aging
  • Burn
  • IL-6
  • LPS
  • Liver

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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