Comparison of the effect of several gastrin-related compounds on acid secretion in dogs

Thomas R. Gadacz, Lawrence W. Way

Research output: Contribution to journalArticle

Abstract

Caerulein, desulfated caerulein, the octapeptide of cholecystokinin, cholecystokinin, and pentagastrin were compared for stimulation of acid secretion from Heidenhain pouches in dogs. Pentagastrin and desulfated caerulein evoked similar maximal rates of secretion. Caerulein and octapeptide of cholecystokinin elicited similar dose-response curves and the maximal secretory rates with these two peptides were less than 50 per cent of that of pentagastrin. Cholecystokinin failed to stimulate pouch secretion over a wide range of doses. When cholecystokinin was added to an infusion of caerulein, acid secretion was inhibited. We interpret these findings as follows: (1) sulfation of tyrosyl in position 7 from the C-terminus in peptides with the active center of gastrin is the essential feature which changes these compounds from full agonists to partial agonists for gastric secretion in dogs; (2) the difference between natural cholecystokinin and the synthetic octapeptide of cholecystokinin for acid secretion probably is due to an enterogastrone other than cholecystokinin or secretin in the cholecystokinin preparation.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalAmerican Journal of Surgery
Volume123
Issue number2
DOIs
StatePublished - 1972
Externally publishedYes

Fingerprint

Cholecystokinin
Gastrins
Ceruletide
Dogs
Sincalide
Pentagastrin
Acids
Secretory Rate
Peptides
Secretin
Stomach

ASJC Scopus subject areas

  • Surgery

Cite this

Comparison of the effect of several gastrin-related compounds on acid secretion in dogs. / Gadacz, Thomas R.; Way, Lawrence W.

In: American Journal of Surgery, Vol. 123, No. 2, 1972, p. 143-148.

Research output: Contribution to journalArticle

Gadacz, Thomas R. ; Way, Lawrence W. / Comparison of the effect of several gastrin-related compounds on acid secretion in dogs. In: American Journal of Surgery. 1972 ; Vol. 123, No. 2. pp. 143-148.
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