Comparison of synthetic serum substitute and fetal cord serum as media supplements for in vitro fertilization: A prospective, randomized study

Kimberly J. Dugan, Sian Shalika, Rosella D. Smith, Santiago L. Padilla

Research output: Contribution to journalArticle

Abstract

Objective: To compare the value of synthetic serum substitute and fetal cord serum (FCS) as protein supplements in the media used for IVF. Design: Prospective, randomized study of 45 patients undergoing IVF. Setting: Private infertility practice. Intervention(s): The protein supplement for use in IVF medium was randomized prospectively to synthetic serum substitute or FCS. Main Outcome Measure(s): Oocyte fertilization rate, incidence of embryo arrest, number of embryos transferred, ongoing pregnancy rate, and implantation rate were assessed. Result(s): There was no significant difference in the fertilization rate, incidence of embryo arrest, number of embryos transferred, ongoing pregnancy rate, and implantation rate. Conclusion(s): Synthetic serum substitute is a better alternative to FCS as a protein supplement for IVF because of its availability and cost effectiveness. Synthetic serum substitute can he used in culture medium for sperm washing, insemination, culture, and transfer translating to decreased technician time without a significant difference in fertilization, pregnancy, or implantation rate.

Original languageEnglish (US)
Pages (from-to)166-168
Number of pages3
JournalFertility and sterility
Volume67
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Culture media
  • IVF
  • fertilization rate
  • fetal cord serum
  • ongoing pregnancy rate
  • synthetic serum substitute

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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