Comparison of [11C]diprenorphine and [11C]carfentanil in vivo binding to opiate receptors in man using a dual detector system

Victor L. Villemagne, J. James Frost, Robert F. Dannals, John R. Lever, Shuji Tanada, T. K. Natarajan, Alan A. Wilson, Hayden T. Ravert, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

A simple dual detector coincidence system was used to measure the binding of [11C]carfentanil and [11C]diprenorphine to opiate receptors in normal volunteers before and after the administration of naloxone. Total radioactivity without naloxone and the ratio of total/non-specific radioactivity was 2 times greater for [11C]diprenorphine than [11C]carfentanil. The dose of naloxone required to maximally block specific [11C]diprenorphine binding was 10 times that for [11C]carfentanil, indicating that [11C]diprenorphine labels opiate receptor subtypes in addition to μ opiate receptors.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalEuropean Journal of Pharmacology
Volume257
Issue number1-2
DOIs
StatePublished - May 12 1994

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Keywords

  • Dual detector system
  • Opiate receptor
  • Positron emitting tracer

ASJC Scopus subject areas

  • Pharmacology

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