Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension

Yoshiaki Ohyama, Bharath Ambale Venkatesh, Elzbieta Chamera, Monda L. Shehata, Celia P. Corona-Villalobos, Stefan Zimmerman, Paul M Hassoun, David A. Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

Background Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. Methods In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT. LV peak global circumferential strains (Ecc) by MTT were measured from short axis. For validation, RV and LV Ell by MTT were compared to measures by SENC-MRI from short axis, and LV Ecc by MTT was compared to measures by short axis tagged MRI analysis (HARP). Reproducibility of MTT was also determined. Results MTT quantified RV Ell correlated closely to those of SENC (r = 0.72, p <0.001), with good limits of agreement. LV Ell quantified by MTT showed moderate correlation with SENC (r = 0.57, p = 0.001), and LV Ecc by MTT also showed moderate correlation with HARP (- 16.9 ± 4.1 vs - 14.3 ± 3.5, p <0.001 for all, r = 0.60, p <0.001). RV Ell negatively correlated with RVEF (r = - 0.53, p = 0.001) and also positively correlated with mean PAP in PH patients (r = 0.60, p = 0.001). Strain measurement by MTT showed high reproducibility. Conclusions We demonstrate that MTT is a reproducible tool for quantification of cardiac deformation using cine images in PH patients. Hence, it could serve as a new rapid and comprehensive technique for clinical assessment of regional cardiac function.

Original languageEnglish (US)
Pages (from-to)342-348
Number of pages7
JournalInternational Journal of Cardiology
Volume182
DOIs
StatePublished - Mar 1 2015

Fingerprint

Pulmonary Hypertension
Cine Magnetic Resonance Imaging

Keywords

  • Abbreviations PH pulmonary hypertension
  • Ecc circumferential strain.
  • Ell longitudinal strain
  • HARP harmonic phase analysis
  • LV left ventricle
  • MTT multimodality tissue tracking
  • RV right ventricle
  • SENC strain-encoding

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension. / Ohyama, Yoshiaki; Ambale Venkatesh, Bharath; Chamera, Elzbieta; Shehata, Monda L.; Corona-Villalobos, Celia P.; Zimmerman, Stefan; Hassoun, Paul M; Bluemke, David A.; Lima, Joao.

In: International Journal of Cardiology, Vol. 182, 01.03.2015, p. 342-348.

Research output: Contribution to journalArticle

@article{f6e82f15122a4cb19662acfed75d5bd5,
title = "Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension",
abstract = "Background Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. Methods In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT. LV peak global circumferential strains (Ecc) by MTT were measured from short axis. For validation, RV and LV Ell by MTT were compared to measures by SENC-MRI from short axis, and LV Ecc by MTT was compared to measures by short axis tagged MRI analysis (HARP). Reproducibility of MTT was also determined. Results MTT quantified RV Ell correlated closely to those of SENC (r = 0.72, p <0.001), with good limits of agreement. LV Ell quantified by MTT showed moderate correlation with SENC (r = 0.57, p = 0.001), and LV Ecc by MTT also showed moderate correlation with HARP (- 16.9 ± 4.1 vs - 14.3 ± 3.5, p <0.001 for all, r = 0.60, p <0.001). RV Ell negatively correlated with RVEF (r = - 0.53, p = 0.001) and also positively correlated with mean PAP in PH patients (r = 0.60, p = 0.001). Strain measurement by MTT showed high reproducibility. Conclusions We demonstrate that MTT is a reproducible tool for quantification of cardiac deformation using cine images in PH patients. Hence, it could serve as a new rapid and comprehensive technique for clinical assessment of regional cardiac function.",
keywords = "Abbreviations PH pulmonary hypertension, Ecc circumferential strain., Ell longitudinal strain, HARP harmonic phase analysis, LV left ventricle, MTT multimodality tissue tracking, RV right ventricle, SENC strain-encoding",
author = "Yoshiaki Ohyama and {Ambale Venkatesh}, Bharath and Elzbieta Chamera and Shehata, {Monda L.} and Corona-Villalobos, {Celia P.} and Stefan Zimmerman and Hassoun, {Paul M} and Bluemke, {David A.} and Joao Lima",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.ijcard.2015.01.016",
language = "English (US)",
volume = "182",
pages = "342--348",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Comparison of strain measurement from multimodality tissue tracking with strain-encoding MRI and harmonic phase MRI in pulmonary hypertension

AU - Ohyama, Yoshiaki

AU - Ambale Venkatesh, Bharath

AU - Chamera, Elzbieta

AU - Shehata, Monda L.

AU - Corona-Villalobos, Celia P.

AU - Zimmerman, Stefan

AU - Hassoun, Paul M

AU - Bluemke, David A.

AU - Lima, Joao

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Background Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. Methods In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT. LV peak global circumferential strains (Ecc) by MTT were measured from short axis. For validation, RV and LV Ell by MTT were compared to measures by SENC-MRI from short axis, and LV Ecc by MTT was compared to measures by short axis tagged MRI analysis (HARP). Reproducibility of MTT was also determined. Results MTT quantified RV Ell correlated closely to those of SENC (r = 0.72, p <0.001), with good limits of agreement. LV Ell quantified by MTT showed moderate correlation with SENC (r = 0.57, p = 0.001), and LV Ecc by MTT also showed moderate correlation with HARP (- 16.9 ± 4.1 vs - 14.3 ± 3.5, p <0.001 for all, r = 0.60, p <0.001). RV Ell negatively correlated with RVEF (r = - 0.53, p = 0.001) and also positively correlated with mean PAP in PH patients (r = 0.60, p = 0.001). Strain measurement by MTT showed high reproducibility. Conclusions We demonstrate that MTT is a reproducible tool for quantification of cardiac deformation using cine images in PH patients. Hence, it could serve as a new rapid and comprehensive technique for clinical assessment of regional cardiac function.

AB - Background Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. Methods In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT. LV peak global circumferential strains (Ecc) by MTT were measured from short axis. For validation, RV and LV Ell by MTT were compared to measures by SENC-MRI from short axis, and LV Ecc by MTT was compared to measures by short axis tagged MRI analysis (HARP). Reproducibility of MTT was also determined. Results MTT quantified RV Ell correlated closely to those of SENC (r = 0.72, p <0.001), with good limits of agreement. LV Ell quantified by MTT showed moderate correlation with SENC (r = 0.57, p = 0.001), and LV Ecc by MTT also showed moderate correlation with HARP (- 16.9 ± 4.1 vs - 14.3 ± 3.5, p <0.001 for all, r = 0.60, p <0.001). RV Ell negatively correlated with RVEF (r = - 0.53, p = 0.001) and also positively correlated with mean PAP in PH patients (r = 0.60, p = 0.001). Strain measurement by MTT showed high reproducibility. Conclusions We demonstrate that MTT is a reproducible tool for quantification of cardiac deformation using cine images in PH patients. Hence, it could serve as a new rapid and comprehensive technique for clinical assessment of regional cardiac function.

KW - Abbreviations PH pulmonary hypertension

KW - Ecc circumferential strain.

KW - Ell longitudinal strain

KW - HARP harmonic phase analysis

KW - LV left ventricle

KW - MTT multimodality tissue tracking

KW - RV right ventricle

KW - SENC strain-encoding

UR - http://www.scopus.com/inward/record.url?scp=84947202794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947202794&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2015.01.016

DO - 10.1016/j.ijcard.2015.01.016

M3 - Article

VL - 182

SP - 342

EP - 348

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -