@article{7dcee2c2edf04d1aaeba0e963b02afdb,
title = "Comparison of Spectral- and Time-Domain Optical Coherence Tomography for Retinal Thickness Measurements in Healthy and Diseased Eyes",
abstract = "Purpose: To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses. Design: Retrospective, observational chart review. Methods: Scans of 184 healthy and diseased eyes from 106 patients were included in the study. Pair-wise comparisons of RT measurements from SD-OCT machines from 2 different manufacturers and TD-OCT were performed for all scans and with eyes stratified by disease diagnosis. Results: Foveal thickness measurements obtained from both SD-OCT machines were greater than those measured by TD-OCT, by 51.0 ± 23.8 μm and 72.5 ± 30.4 μm, respectively. The foveal thickness difference between the 2 SD-OCT models was 24.3 ± 19.1 μm. Foveal thickness differences varied by disease diagnosis. Conclusions: RT measurements obtained by SD-OCT are consistently greater than those obtained by TD-OCT. RT measurement differences may vary by disease diagnosis or by SD-OCT model. Consideration of these measurement differences is essential when OCT-determined RT measurement data are used in clinical settings.",
author = "Han, {Ian C.} and Jaffe, {Glenn J.}",
note = "Funding Information: Ian Han will receive his MD degree from the Duke University School of Medicine in May 2009. His research was mentored by Dr Glenn Jaffe at the Duke University Eye Center and supported by the Howard Hughes Medical Institute. Mr Han plans to pursue an academic medical career in ophthalmology and remain active in basic science and clinical research. Funding Information: This study was supported by the Howard Hughes Medical Institute Medical Student Research Training Fellowship, Chevy Chase, Maryland and the National Eye Institute, Bethesda, Maryland, Core Grant P30EY05722. The authors indicate no financial conflict of interest. Involved in design and conduct of study (G.J.J., I.C.H.); collection and management of data (I.C.H.); analysis and interpretation of data (G.J.J., I.C.H.); and manuscript preparation, review, and approval (G.J.J., I.C.H.). The study and data accumulation were carried out with approval from the Institutional Review Board of Duke University Medical Center, Durham, North Carolina, and performed in accordance with HIPAA regulations. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2009",
month = may,
doi = "10.1016/j.ajo.2008.11.019",
language = "English (US)",
volume = "147",
pages = "847--858.e1",
journal = "American journal of ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "5",
}