Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)

Benjamin M. Smith, Eric A. Hoffman, Dan Rabinowitz, Eugene Bleecker, Stephanie Christenson, David Couper, Kathleen M. Donohue, Meilan K. Han, Nadia Hansel, Richard E. Kanner, Eric Kleerup, Stephen Rennard, R. Graham Barr

Research output: Contribution to journalArticle

Abstract

Background: COPD is characterised by reduced airway lumen dimensions and fewer peripheral airways. Most studies of airway properties sample airways based upon lumen dimension or at random, which may bias comparisons given reduced airway lumen dimensions and number in COPD. We sought to compare central airway wall dimensions on CT in COPD and controls using spatially matched airways, thereby avoiding selection bias of airways in the lung. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) recruited smokers with COPD and controls aged 50-79 years and 40-80 years, respectively. COPD was defined by current guidelines. Using CT image data, airway dimensions were measured for all central airway segments (generations 0-6) following 5 standardised paths into the lungs. Case-control airway comparisons were spatially matched by generation and adjusted for demographics, body size, smoking, CT dose, per cent emphysema, airway length and lung volume. Results: Among 311 MESA COPD participants, airway wall areas at generations 3-6 were smaller in COPD compared with controls (all p

Original languageEnglish (US)
Pages (from-to)987-996
Number of pages10
JournalThorax
Volume69
Issue number11
DOIs
StatePublished - Nov 1 2014

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Chronic Obstructive Pulmonary Disease
Atherosclerosis
Lung
Airway Management
Selection Bias
Emphysema
Body Size
Smoking
Demography
Guidelines

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). / Smith, Benjamin M.; Hoffman, Eric A.; Rabinowitz, Dan; Bleecker, Eugene; Christenson, Stephanie; Couper, David; Donohue, Kathleen M.; Han, Meilan K.; Hansel, Nadia; Kanner, Richard E.; Kleerup, Eric; Rennard, Stephen; Barr, R. Graham.

In: Thorax, Vol. 69, No. 11, 01.11.2014, p. 987-996.

Research output: Contribution to journalArticle

Smith, BM, Hoffman, EA, Rabinowitz, D, Bleecker, E, Christenson, S, Couper, D, Donohue, KM, Han, MK, Hansel, N, Kanner, RE, Kleerup, E, Rennard, S & Barr, RG 2014, 'Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)', Thorax, vol. 69, no. 11, pp. 987-996. https://doi.org/10.1136/thoraxjnl-2014-205160
Smith, Benjamin M. ; Hoffman, Eric A. ; Rabinowitz, Dan ; Bleecker, Eugene ; Christenson, Stephanie ; Couper, David ; Donohue, Kathleen M. ; Han, Meilan K. ; Hansel, Nadia ; Kanner, Richard E. ; Kleerup, Eric ; Rennard, Stephen ; Barr, R. Graham. / Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). In: Thorax. 2014 ; Vol. 69, No. 11. pp. 987-996.
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