Abstract
This study reports on ethnic differences in bone mass before and after adjusting for differences in body size and bone area (BA). Lumbar spine (LSBMC), proximal femur (PFBMC) and femoral neck (FNBMC) bone mineral contents were measured in black ('black'; n = 263) and white ('white'; n = 73) children from Johannesburg and children of mixed ancestral origin ('mixed'; n = 64) from Cape Town, South Africa. Geometric estimates and the power coefficient from the regression analyses of BMC on BA were calculated. After adjusting for age, weight, and height, LSBMC in girls and FNBMC in girls and boys were greatest in mixed, followed by black and then white, groups. Mixed boys and girls also had greater PFBMC than their black and white peers, but only in the boys was PFBMC greater in the black than the white groups. When including BA in the adjustment, differences remained at the FN in boys and girls, and the LS and PF in girls, but disappeared at the PF in mixed and black boys. The difference in LSBMC between mixed and black boys became significant after adjustment for age, weight, height, and BA. Geometric estimates at the femoral neck were greater in the mixed group. Power coefficients were greater in the white group, suggesting differences in shape or bone distribution. In conclusion, this study suggests that, in addition to differences in BMC, differences in bone strength and geometry are present which might confer advantages to the bone of mixed-ancestry children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 317-325 |
| Number of pages | 9 |
| Journal | Calcified Tissue International |
| Volume | 85 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2009 |
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Keywords
- Bone mass
- Bone strength
- Children
- Dual-energy X-ray absorptiometry
- Ethnicity
- South Africa
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Comparison of site-specific bone mass indices in south african children of different ethnic groups. / Micklesfield, L. K.; Norris, S. A.; Van Der Merwe, L.; Lambert, E. V.; Beck, T.; Pettifor, J. M.
In: Calcified Tissue International, Vol. 85, No. 4, 10.2009, p. 317-325.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of site-specific bone mass indices in south african children of different ethnic groups
AU - Micklesfield, L. K.
AU - Norris, S. A.
AU - Van Der Merwe, L.
AU - Lambert, E. V.
AU - Beck, T.
AU - Pettifor, J. M.
PY - 2009/10
Y1 - 2009/10
N2 - This study reports on ethnic differences in bone mass before and after adjusting for differences in body size and bone area (BA). Lumbar spine (LSBMC), proximal femur (PFBMC) and femoral neck (FNBMC) bone mineral contents were measured in black ('black'; n = 263) and white ('white'; n = 73) children from Johannesburg and children of mixed ancestral origin ('mixed'; n = 64) from Cape Town, South Africa. Geometric estimates and the power coefficient from the regression analyses of BMC on BA were calculated. After adjusting for age, weight, and height, LSBMC in girls and FNBMC in girls and boys were greatest in mixed, followed by black and then white, groups. Mixed boys and girls also had greater PFBMC than their black and white peers, but only in the boys was PFBMC greater in the black than the white groups. When including BA in the adjustment, differences remained at the FN in boys and girls, and the LS and PF in girls, but disappeared at the PF in mixed and black boys. The difference in LSBMC between mixed and black boys became significant after adjustment for age, weight, height, and BA. Geometric estimates at the femoral neck were greater in the mixed group. Power coefficients were greater in the white group, suggesting differences in shape or bone distribution. In conclusion, this study suggests that, in addition to differences in BMC, differences in bone strength and geometry are present which might confer advantages to the bone of mixed-ancestry children.
AB - This study reports on ethnic differences in bone mass before and after adjusting for differences in body size and bone area (BA). Lumbar spine (LSBMC), proximal femur (PFBMC) and femoral neck (FNBMC) bone mineral contents were measured in black ('black'; n = 263) and white ('white'; n = 73) children from Johannesburg and children of mixed ancestral origin ('mixed'; n = 64) from Cape Town, South Africa. Geometric estimates and the power coefficient from the regression analyses of BMC on BA were calculated. After adjusting for age, weight, and height, LSBMC in girls and FNBMC in girls and boys were greatest in mixed, followed by black and then white, groups. Mixed boys and girls also had greater PFBMC than their black and white peers, but only in the boys was PFBMC greater in the black than the white groups. When including BA in the adjustment, differences remained at the FN in boys and girls, and the LS and PF in girls, but disappeared at the PF in mixed and black boys. The difference in LSBMC between mixed and black boys became significant after adjustment for age, weight, height, and BA. Geometric estimates at the femoral neck were greater in the mixed group. Power coefficients were greater in the white group, suggesting differences in shape or bone distribution. In conclusion, this study suggests that, in addition to differences in BMC, differences in bone strength and geometry are present which might confer advantages to the bone of mixed-ancestry children.
KW - Bone mass
KW - Bone strength
KW - Children
KW - Dual-energy X-ray absorptiometry
KW - Ethnicity
KW - South Africa
UR - http://www.scopus.com/inward/record.url?scp=70349967958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349967958&partnerID=8YFLogxK
U2 - 10.1007/s00223-009-9286-y
DO - 10.1007/s00223-009-9286-y
M3 - Article
VL - 85
SP - 317
EP - 325
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 4
ER -