Comparison of single voxel brain MRS AT 3T and 7T using 32-channel head coils

Subechhya Pradhan, Susanne Bonekamp, Joseph S. Gillen, Laura M. Rowland, S. Andrea Wijtenburg, Richard A.E. Edden, Peter B. Barker

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The purpose of this study was to compare magnetic resonance spectroscopy (MRS) of three different regions of the human brain between 3 and 7 Tesla, using the same subjects and closely matched methodology at both field strengths. Methods: A semi-LASER (sLASER) pulse sequence with TE 32 ms was used to acquire metabolite spectrum along with the water reference at 3 T and 7 T using similar experimental parameters and hardware at both field strengths (n=4 per region and field). Spectra were analyzed in LCModel using a simulated basis set. Results: Signal-to-noise ratio (SNR) at 7 T was higher compared to 3 T, and linewidths (in ppm) at both field strengths were comparable in ppm scale. Of the 13 metabolites reported in the paper, most metabolites were measured with higher precision at 7 T in all three regions. Conclusion: The study confirms gains in SNR and measurement precision at 7 T in all three representative brain regions using the sLASER pulse sequence coupled with a 32-channel phased-array head coil.

Original languageEnglish (US)
Pages (from-to)1013-1018
Number of pages6
JournalMagnetic Resonance Imaging
Volume33
Issue number8
DOIs
StatePublished - Oct 1 2015

Keywords

  • 3 Tesla
  • 7 Tesla
  • Brain
  • Magnetic resonance spectroscopy
  • Semi-LASER

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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