Abstract
The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance- components method had better power for detection of linkage, particularly when covariates were included in the model. Type 1 error rates were similar to nominal error rates for both methods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 867-872 |
| Number of pages | 6 |
| Journal | Genetic epidemiology |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1997 |
Keywords
- Linkage
- Sib-pair method
- Statistical power
- Type I error
- Variance- components method
ASJC Scopus subject areas
- Epidemiology
- Genetics(clinical)