Comparison of sib-pair and variance-components methods for genomic screening

Elizabeth W. Pugh, Cashell E. Jaquish, Alexa J.M. Sorant, Jennifer P. Doetsch, Joan E. Bailey-Wilson, Alexander F. Wilson

Research output: Contribution to journalArticlepeer-review


The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance- components method had better power for detection of linkage, particularly when covariates were included in the model. Type 1 error rates were similar to nominal error rates for both methods.

Original languageEnglish (US)
Pages (from-to)867-872
Number of pages6
JournalGenetic epidemiology
Issue number6
StatePublished - 1997


  • Linkage
  • Sib-pair method
  • Statistical power
  • Type I error
  • Variance- components method

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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