Comparison of scatter compensation strategies for myocardial perfusion imaging using Tc-99m labeled sestamibi

Yigal S. Gur; Troy H. Farncombe; P. Hendrik Pretorius; Howard C. Gifford; Manoj V. Narayanan; Eric C. Frey; Daniel Gagnon; Michael A. King

doi:10.1109/TNS.2002.803859

Comparison of scatter compensation strategies for myocardial perfusion imaging using Tc-99m labeled sestamibi

Yigal S. Gur, Troy H. Farncombe, P. Hendrik Pretorius, Howard C. Gifford, Manoj V. Narayanan, Eric C. Frey, Daniel Gagnon, Michael A. King

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Scatter can be a confounding problem in the detection of perfusion defects in myocardial perfusion imaging. The goal of this investigation was to compare practical methods of scatter compensation representing different classes of compensation strategies. The methods investigated were: 1) modification of the energy window; 2) use of effective values of attenuation coefficients; 3) estimating the scatter distribution from energy spectrum information; and 4) estimating the scatter distribution in the spatial domain using the attenuation maps and scatter kernels. Monte Carlo simulated projections from two MCAT source distributions were used to investigate the impact of the various methods on residual scatter and myocardial uniformity. The investigation showed that each of the methods reduce the scatter significantly; however, the spatial domain method gave the least variation with the different source distributions and the best uniformity.

Original language	English (US)
Pages (from-to)	2309-2314
Number of pages	6
Journal	IEEE Transactions on Nuclear Science
Volume	49 I
Issue number	5
DOIs	https://doi.org/10.1109/TNS.2002.803859
State	Published - Oct 2002
Externally published	Yes

Keywords

Cardiac
SPECT
Scatter compensation

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

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10.1109/TNS.2002.803859

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title = "Comparison of scatter compensation strategies for myocardial perfusion imaging using Tc-99m labeled sestamibi",

abstract = "Scatter can be a confounding problem in the detection of perfusion defects in myocardial perfusion imaging. The goal of this investigation was to compare practical methods of scatter compensation representing different classes of compensation strategies. The methods investigated were: 1) modification of the energy window; 2) use of effective values of attenuation coefficients; 3) estimating the scatter distribution from energy spectrum information; and 4) estimating the scatter distribution in the spatial domain using the attenuation maps and scatter kernels. Monte Carlo simulated projections from two MCAT source distributions were used to investigate the impact of the various methods on residual scatter and myocardial uniformity. The investigation showed that each of the methods reduce the scatter significantly; however, the spatial domain method gave the least variation with the different source distributions and the best uniformity.",

keywords = "Cardiac, SPECT, Scatter compensation",

author = "Gur, {Yigal S.} and Farncombe, {Troy H.} and Pretorius, {P. Hendrik} and Gifford, {Howard C.} and Narayanan, {Manoj V.} and Frey, {Eric C.} and Daniel Gagnon and King, {Michael A.}",

note = "Funding Information: Manuscript received December 4, 2001; revised June 8, 2002. This work was supported in part by the National Heart, Lung and Blood Institute Grant HL-50349. The contents are solely the responsibility of the authors and do not represent the official views of the National Heart, Lung and Blood Institute.",

year = "2002",

month = oct,

doi = "10.1109/TNS.2002.803859",

language = "English (US)",

volume = "49 I",

pages = "2309--2314",

journal = "IEEE Transactions on Nuclear Science",

issn = "0018-9499",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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T1 - Comparison of scatter compensation strategies for myocardial perfusion imaging using Tc-99m labeled sestamibi

AU - Gur, Yigal S.

AU - Farncombe, Troy H.

AU - Pretorius, P. Hendrik

AU - Gifford, Howard C.

AU - Narayanan, Manoj V.

AU - Frey, Eric C.

AU - Gagnon, Daniel

AU - King, Michael A.

N1 - Funding Information: Manuscript received December 4, 2001; revised June 8, 2002. This work was supported in part by the National Heart, Lung and Blood Institute Grant HL-50349. The contents are solely the responsibility of the authors and do not represent the official views of the National Heart, Lung and Blood Institute.

PY - 2002/10

Y1 - 2002/10

N2 - Scatter can be a confounding problem in the detection of perfusion defects in myocardial perfusion imaging. The goal of this investigation was to compare practical methods of scatter compensation representing different classes of compensation strategies. The methods investigated were: 1) modification of the energy window; 2) use of effective values of attenuation coefficients; 3) estimating the scatter distribution from energy spectrum information; and 4) estimating the scatter distribution in the spatial domain using the attenuation maps and scatter kernels. Monte Carlo simulated projections from two MCAT source distributions were used to investigate the impact of the various methods on residual scatter and myocardial uniformity. The investigation showed that each of the methods reduce the scatter significantly; however, the spatial domain method gave the least variation with the different source distributions and the best uniformity.

AB - Scatter can be a confounding problem in the detection of perfusion defects in myocardial perfusion imaging. The goal of this investigation was to compare practical methods of scatter compensation representing different classes of compensation strategies. The methods investigated were: 1) modification of the energy window; 2) use of effective values of attenuation coefficients; 3) estimating the scatter distribution from energy spectrum information; and 4) estimating the scatter distribution in the spatial domain using the attenuation maps and scatter kernels. Monte Carlo simulated projections from two MCAT source distributions were used to investigate the impact of the various methods on residual scatter and myocardial uniformity. The investigation showed that each of the methods reduce the scatter significantly; however, the spatial domain method gave the least variation with the different source distributions and the best uniformity.

KW - Cardiac

KW - SPECT

KW - Scatter compensation

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JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 5

ER -

Comparison of scatter compensation strategies for myocardial perfusion imaging using Tc-99m labeled sestamibi

Abstract

Keywords

ASJC Scopus subject areas

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