TY - JOUR
T1 - Comparison of rosuvastatin versus atorvastatin in patients with heterozygous familial hypercholesterolemia
AU - Stein, Evan A.
AU - Strutt, Kristina
AU - Southworth, Harry
AU - Diggle, Peter J.
AU - Miller, Elinor
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Heterozygous familial hypercholesterolemia (HFH) is a common genetic disorder that confers a significantly increased risk of early coronary artery disease. This study compared atorvastatin and rosuvastatin in reducing low-density lipoprotein (LDL) cholesterol in HFH in a global, 18-week, weighted-randomization, double-blind, parallel-group, forced-titration study. Following a 6-week diet lead-in, 623 patients were randomized to 20 mg/day of atorvastatin (n = 187) or rosuvastatin (n = 436) with forced titration at 6-week intervals to 80 mg/day. The primary end point was percentage change in LDL cholesterol from baseline to week 18. At week 18, rosuvastatin therapy produced a significantly greater reduction in LDL cholesterol than atorvastatin (-57.9% vs -50.4%; p
AB - Heterozygous familial hypercholesterolemia (HFH) is a common genetic disorder that confers a significantly increased risk of early coronary artery disease. This study compared atorvastatin and rosuvastatin in reducing low-density lipoprotein (LDL) cholesterol in HFH in a global, 18-week, weighted-randomization, double-blind, parallel-group, forced-titration study. Following a 6-week diet lead-in, 623 patients were randomized to 20 mg/day of atorvastatin (n = 187) or rosuvastatin (n = 436) with forced titration at 6-week intervals to 80 mg/day. The primary end point was percentage change in LDL cholesterol from baseline to week 18. At week 18, rosuvastatin therapy produced a significantly greater reduction in LDL cholesterol than atorvastatin (-57.9% vs -50.4%; p
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U2 - 10.1016/j.amjcard.2003.08.009
DO - 10.1016/j.amjcard.2003.08.009
M3 - Article
C2 - 14636905
AN - SCOPUS:0242544064
SN - 0002-9149
VL - 92
SP - 1287
EP - 1293
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 11
ER -