TY - JOUR
T1 - Comparison of risk and age at diagnosis of myocardial infarction, end-stage renal disease, and non-AIDS-defining cancer in HIV-infected versus uninfected adults
AU - Althoff, Keri N.
AU - McGinnis, Kathleen A.
AU - Wyatt, Christina M.
AU - Freiberg, Matthew S.
AU - Gilbert, Cynthia
AU - Oursler, Krisann K.
AU - Rimland, David
AU - Rodriguez-Barradas, Maria C.
AU - Dubrow, Robert
AU - Park, Lesley S.
AU - Skanderson, Melissa
AU - Shiels, Meredith S.
AU - Gange, Stephen J.
AU - Gebo, Kelly A.
AU - Justice, Amy C.
N1 - Publisher Copyright:
© The Author 2014.
PY - 2015/2/15
Y1 - 2015/2/15
N2 - Background.Although it has been shown that human immunodeficiency virus (HIV)-infected adults are at greater risk for aging-associated events, it remains unclear as to whether these events happen at similar, or younger ages, in HIV-infected compared with uninfected adults. The objective of this study was to compare the median age at, and risk of, incident diagnosis of 3 age-associated diseases in HIV-infected and demographically similar uninfected adults. Methods.The study was nested in the clinical prospective Veterans Aging Cohort Study of HIV-infected and demographically matched uninfected veterans, from 1 April 2003 to 31 December 2010. The outcomes were validated diagnoses of myocardial infarction (MI), end-stage renal disease (ESRD), and non-AIDS-defining cancer (NADC). Differences in mean age at, and risk of, diagnosis by HIV status were estimated using multivariate linear regression models and Cox proportional hazards models, respectively. Results.A total of 98 687 (31% HIV-infected and 69% uninfected) adults contributed >450 000 person-years and 689 MI, 1135 ESRD, and 4179 NADC incident diagnoses. Mean age at MI (adjusted mean difference, -0.11; 95% confidence interval [CI], -.59 to. 37 years) and NADC (adjusted mean difference, -0.10 [95% CI, -.30 to. 10] years) did not differ by HIV status. HIV-infected adults were diagnosed with ESRD at an average age of 5.5 months younger than uninfected adults (adjusted mean difference, -0.46 [95% CI, -.86 to -.07] years). HIV-infected adults had a greater risk of all 3 outcomes compared with uninfected adults after accounting for important confounders. Conclusions.HIV-infected adults had a higher risk of these age-associated events, but they occurred at similar ages than those without HIV.
AB - Background.Although it has been shown that human immunodeficiency virus (HIV)-infected adults are at greater risk for aging-associated events, it remains unclear as to whether these events happen at similar, or younger ages, in HIV-infected compared with uninfected adults. The objective of this study was to compare the median age at, and risk of, incident diagnosis of 3 age-associated diseases in HIV-infected and demographically similar uninfected adults. Methods.The study was nested in the clinical prospective Veterans Aging Cohort Study of HIV-infected and demographically matched uninfected veterans, from 1 April 2003 to 31 December 2010. The outcomes were validated diagnoses of myocardial infarction (MI), end-stage renal disease (ESRD), and non-AIDS-defining cancer (NADC). Differences in mean age at, and risk of, diagnosis by HIV status were estimated using multivariate linear regression models and Cox proportional hazards models, respectively. Results.A total of 98 687 (31% HIV-infected and 69% uninfected) adults contributed >450 000 person-years and 689 MI, 1135 ESRD, and 4179 NADC incident diagnoses. Mean age at MI (adjusted mean difference, -0.11; 95% confidence interval [CI], -.59 to. 37 years) and NADC (adjusted mean difference, -0.10 [95% CI, -.30 to. 10] years) did not differ by HIV status. HIV-infected adults were diagnosed with ESRD at an average age of 5.5 months younger than uninfected adults (adjusted mean difference, -0.46 [95% CI, -.86 to -.07] years). HIV-infected adults had a greater risk of all 3 outcomes compared with uninfected adults after accounting for important confounders. Conclusions.HIV-infected adults had a higher risk of these age-associated events, but they occurred at similar ages than those without HIV.
KW - HIV infection
KW - aging
KW - end-stage renal disease
KW - myocardial infarction
KW - non-AIDS-defining cancers
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U2 - 10.1093/cid/ciu869
DO - 10.1093/cid/ciu869
M3 - Article
C2 - 25362204
AN - SCOPUS:84922387803
SN - 1058-4838
VL - 60
SP - 627
EP - 638
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -