Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat

H. C. Champion, J. A. Santiago, M. A. Czapla, Trinity Bivalacqua, C. Ilgenfritz, P. J. Kadowitz

Research output: Contribution to journalArticle

Abstract

Responses to T-kinin and bradykinin were compared in the mesenteric vascular bed of the cat. Under constant-flow conditions, injection of T- kinin and bradykinin into the perfusion circuit induced similar dose-related decreases in perfusion pressure. Responses to T-kinin and bradykinin were inhibited by the kinin B2 receptor antagonist Hoe-140, but were not altered by the B1 receptor antagonist des-Arg9-[Leu8]-BK, the histamine H1 antagonist pyrilamine, the histamine H2 receptor antagonist cimetidine, or the H3 receptor antagonist thioperamide. Vasodilator responses to T-kinin and bradykinin were attenuated by the nitric oxide synthase inhibitor, N(ω) Nitro-L-arginine methyl ester (L-NAME), but were not altered by the cyclooxygenase inhibitor, sodium meclofenamate, or the K+(ATP) channel antagonist, U37883A. These data suggest that vasodilator responses to T- kinin and bradykinin are mediated by kinin B2 receptor stimulated release of nitric oxide from the endothelium, but that the activation of kinin B1 receptors, the release of vasodilator prostaglandins, or the opening of K+(ATP) channels are not involved in the response to T-kinin in the mesenteric vascular bed of the cat.

Original languageEnglish (US)
Pages (from-to)1357-1364
Number of pages8
JournalPeptides
Volume18
Issue number9
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

T-kinin
Bradykinin
Blood Vessels
Cats
Kinins
Vasodilator Agents
thioperamide
Perfusion
Adenosine Triphosphate
Histamine H3 Receptors
Meclofenamic Acid
Histamine H1 Antagonists
Histamine H2 Antagonists
Pyrilamine
Arginine
Cyclooxygenase Inhibitors
Cimetidine
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase
Prostaglandins

Keywords

  • Bradykinin
  • Hoe-140
  • Kinin B receptor
  • Nitric oxide
  • Regional vascular bed
  • T-kinin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Champion, H. C., Santiago, J. A., Czapla, M. A., Bivalacqua, T., Ilgenfritz, C., & Kadowitz, P. J. (1997). Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat. Peptides, 18(9), 1357-1364. https://doi.org/10.1016/S0196-9781(97)00197-6

Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat. / Champion, H. C.; Santiago, J. A.; Czapla, M. A.; Bivalacqua, Trinity; Ilgenfritz, C.; Kadowitz, P. J.

In: Peptides, Vol. 18, No. 9, 1997, p. 1357-1364.

Research output: Contribution to journalArticle

Champion, HC, Santiago, JA, Czapla, MA, Bivalacqua, T, Ilgenfritz, C & Kadowitz, PJ 1997, 'Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat', Peptides, vol. 18, no. 9, pp. 1357-1364. https://doi.org/10.1016/S0196-9781(97)00197-6
Champion, H. C. ; Santiago, J. A. ; Czapla, M. A. ; Bivalacqua, Trinity ; Ilgenfritz, C. ; Kadowitz, P. J. / Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat. In: Peptides. 1997 ; Vol. 18, No. 9. pp. 1357-1364.
@article{8385491780f34586978522170bc3c451,
title = "Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat",
abstract = "Responses to T-kinin and bradykinin were compared in the mesenteric vascular bed of the cat. Under constant-flow conditions, injection of T- kinin and bradykinin into the perfusion circuit induced similar dose-related decreases in perfusion pressure. Responses to T-kinin and bradykinin were inhibited by the kinin B2 receptor antagonist Hoe-140, but were not altered by the B1 receptor antagonist des-Arg9-[Leu8]-BK, the histamine H1 antagonist pyrilamine, the histamine H2 receptor antagonist cimetidine, or the H3 receptor antagonist thioperamide. Vasodilator responses to T-kinin and bradykinin were attenuated by the nitric oxide synthase inhibitor, N(ω) Nitro-L-arginine methyl ester (L-NAME), but were not altered by the cyclooxygenase inhibitor, sodium meclofenamate, or the K+(ATP) channel antagonist, U37883A. These data suggest that vasodilator responses to T- kinin and bradykinin are mediated by kinin B2 receptor stimulated release of nitric oxide from the endothelium, but that the activation of kinin B1 receptors, the release of vasodilator prostaglandins, or the opening of K+(ATP) channels are not involved in the response to T-kinin in the mesenteric vascular bed of the cat.",
keywords = "Bradykinin, Hoe-140, Kinin B receptor, Nitric oxide, Regional vascular bed, T-kinin",
author = "Champion, {H. C.} and Santiago, {J. A.} and Czapla, {M. A.} and Trinity Bivalacqua and C. Ilgenfritz and Kadowitz, {P. J.}",
year = "1997",
doi = "10.1016/S0196-9781(97)00197-6",
language = "English (US)",
volume = "18",
pages = "1357--1364",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat

AU - Champion, H. C.

AU - Santiago, J. A.

AU - Czapla, M. A.

AU - Bivalacqua, Trinity

AU - Ilgenfritz, C.

AU - Kadowitz, P. J.

PY - 1997

Y1 - 1997

N2 - Responses to T-kinin and bradykinin were compared in the mesenteric vascular bed of the cat. Under constant-flow conditions, injection of T- kinin and bradykinin into the perfusion circuit induced similar dose-related decreases in perfusion pressure. Responses to T-kinin and bradykinin were inhibited by the kinin B2 receptor antagonist Hoe-140, but were not altered by the B1 receptor antagonist des-Arg9-[Leu8]-BK, the histamine H1 antagonist pyrilamine, the histamine H2 receptor antagonist cimetidine, or the H3 receptor antagonist thioperamide. Vasodilator responses to T-kinin and bradykinin were attenuated by the nitric oxide synthase inhibitor, N(ω) Nitro-L-arginine methyl ester (L-NAME), but were not altered by the cyclooxygenase inhibitor, sodium meclofenamate, or the K+(ATP) channel antagonist, U37883A. These data suggest that vasodilator responses to T- kinin and bradykinin are mediated by kinin B2 receptor stimulated release of nitric oxide from the endothelium, but that the activation of kinin B1 receptors, the release of vasodilator prostaglandins, or the opening of K+(ATP) channels are not involved in the response to T-kinin in the mesenteric vascular bed of the cat.

AB - Responses to T-kinin and bradykinin were compared in the mesenteric vascular bed of the cat. Under constant-flow conditions, injection of T- kinin and bradykinin into the perfusion circuit induced similar dose-related decreases in perfusion pressure. Responses to T-kinin and bradykinin were inhibited by the kinin B2 receptor antagonist Hoe-140, but were not altered by the B1 receptor antagonist des-Arg9-[Leu8]-BK, the histamine H1 antagonist pyrilamine, the histamine H2 receptor antagonist cimetidine, or the H3 receptor antagonist thioperamide. Vasodilator responses to T-kinin and bradykinin were attenuated by the nitric oxide synthase inhibitor, N(ω) Nitro-L-arginine methyl ester (L-NAME), but were not altered by the cyclooxygenase inhibitor, sodium meclofenamate, or the K+(ATP) channel antagonist, U37883A. These data suggest that vasodilator responses to T- kinin and bradykinin are mediated by kinin B2 receptor stimulated release of nitric oxide from the endothelium, but that the activation of kinin B1 receptors, the release of vasodilator prostaglandins, or the opening of K+(ATP) channels are not involved in the response to T-kinin in the mesenteric vascular bed of the cat.

KW - Bradykinin

KW - Hoe-140

KW - Kinin B receptor

KW - Nitric oxide

KW - Regional vascular bed

KW - T-kinin

UR - http://www.scopus.com/inward/record.url?scp=0030693689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030693689&partnerID=8YFLogxK

U2 - 10.1016/S0196-9781(97)00197-6

DO - 10.1016/S0196-9781(97)00197-6

M3 - Article

VL - 18

SP - 1357

EP - 1364

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 9

ER -