TY - JOUR
T1 - Comparison of racial differences in plaque composition and stenosis between HIV-positive and HIV-negative men from the Multicenter AIDS cohort study
AU - Miller, P. Elliott
AU - Budoff, Matthew
AU - Zikusoka, Michelle
AU - Li, Xiuhong
AU - Palella, Frank
AU - Kingsley, Lawrence A.
AU - Witt, Mallory D.
AU - Sharrett, A. Richey
AU - Jacobson, Lisa P.
AU - Post, Wendy S.
N1 - Funding Information:
The Multicenter AIDS Cohort Study (MACS) cardiovascular disease study is funded by grant R01 HL095129 from the National Heart, Lung, and Blood Institute (Dr. Post). Data in this manuscript were collected by the MACS with centers (principal investigators) at Johns Hopkins University Bloomberg School of Public Health (Joseph Margolick), U01-AI35042 ; Northwestern University (Steven Wolinsky), U01-AI35039 ; University of California, Los Angeles (Roger Detels), U01-AI35040 ; University of Pittsburgh (Charles Rinaldo), U01-AI35041 ; the Center for Analysis and Management of MACS, Johns Hopkins University Bloomberg School of Public Health (Dr. Jacobson), UM1-AI35043 . The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases , with additional co-funding from the National Cancer Institute (NCI). MACS data collection is also supported by UL1-TR000424 ( Johns Hopkins University (JHU) Clinical and Translational Science Award (CTSA)). The CTSA award is from National Center for Advancing Translational Sciences (NCATS). Web site located at http://www.statepi.jhsph.edu/macs/macs.html . The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health.
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Previous studies demonstrated that blacks have less coronary artery calcification (CAC) than whites. We evaluated racial differences in plaque composition and stenosis in the Multicenter AIDS Cohort Study. HIV-positive and HIV-negative men underwent noncontrast cardiac computed tomography (CT) if they were aged 40 to 70 years, weighed <136 kg, and had no history of cardiac surgery or revascularization and, if eligible, coronary CT angiography (CTA). There were 1,001 men who underwent CT scans and 759 men CTA. We measured CAC on noncontrast CT and identified total plaque, noncalcified plaque, calcified plaque, mixed plaque, and coronary stenosis >50% on CTA. The association of presence and extent of plaque with race was determined after adjustment for HIV serostatus, cardiovascular risk factors, and measures of socioeconomic status. The prevalences of any plaque on CTA and noncalcified plaque were not different between black and white men; however, black men had lower prevalences of CAC (prevalence ratio [PR] 0.79, p = 0.01), calcified plaque (PR 0.69, p = 0.002), and stenosis >50% (PR 0.59, p = 0.009). There were no associations between black race and extent of plaque in fully adjusted models. Using log-linear regression, black race was associated with a lower extent of any plaque on CTA in HIV-positive men (estimate = -0.24, p = 0.051) but not in HIV-negative men (0.12, p = 0.50, HIV interaction p = 0.005). In conclusion, a lower prevalence of CAC in black compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.
AB - Previous studies demonstrated that blacks have less coronary artery calcification (CAC) than whites. We evaluated racial differences in plaque composition and stenosis in the Multicenter AIDS Cohort Study. HIV-positive and HIV-negative men underwent noncontrast cardiac computed tomography (CT) if they were aged 40 to 70 years, weighed <136 kg, and had no history of cardiac surgery or revascularization and, if eligible, coronary CT angiography (CTA). There were 1,001 men who underwent CT scans and 759 men CTA. We measured CAC on noncontrast CT and identified total plaque, noncalcified plaque, calcified plaque, mixed plaque, and coronary stenosis >50% on CTA. The association of presence and extent of plaque with race was determined after adjustment for HIV serostatus, cardiovascular risk factors, and measures of socioeconomic status. The prevalences of any plaque on CTA and noncalcified plaque were not different between black and white men; however, black men had lower prevalences of CAC (prevalence ratio [PR] 0.79, p = 0.01), calcified plaque (PR 0.69, p = 0.002), and stenosis >50% (PR 0.59, p = 0.009). There were no associations between black race and extent of plaque in fully adjusted models. Using log-linear regression, black race was associated with a lower extent of any plaque on CTA in HIV-positive men (estimate = -0.24, p = 0.051) but not in HIV-negative men (0.12, p = 0.50, HIV interaction p = 0.005). In conclusion, a lower prevalence of CAC in black compared with white men appears to reflect less calcification of plaque and stenosis rather than a lower overall prevalence of plaque.
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U2 - 10.1016/j.amjcard.2014.04.049
DO - 10.1016/j.amjcard.2014.04.049
M3 - Article
C2 - 24929623
AN - SCOPUS:84904259603
SN - 0002-9149
VL - 114
SP - 369
EP - 375
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -