Comparison of postoperative complications between internal and external pancreatic duct stenting during pancreaticoduodenectomy: A meta-analysis

Fa Yong Ke, Xiang Song Wu, Yong Zhang, Hong Cheng Zhang, Ming Zhe Weng, Ying Bin Liu, Christopher Wolfgang, Wei Gong

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Two types of pancreatic duct stents are used to improve postoperative outcomes of pancreatic anastomosis. The aim of this meta-analysis was to evaluate and compare the postoperative outcomes of patients with internal or external stenting during pancreaticoduodenectomy (PD). Methods: We searched PubMed, EMBASE, the Cochrane Library and Web of Science databases until the end of December, 2014. Studies comparing outcomes of external vs. internal stent placement in PD were eligible for inclusion. Included literature was extracted and assessed by two independent reviewers. Results: Seven articles were identified for inclusion: three randomized controlled trials (RCTs) and four observational clinical studies (OCS). The meta-analyses revealed that use of external stents had advantage on reducing the incidences of pancreatic fistula (PF) in total [odds ratio (OR) =0.69; 95% confidence interval (CI), 0.48-0.99; P=0.04], PF in soft pancreas (OR =0.30; 95% CI, 0.16-0.56; P=0.0002) and delayed gastric emptying (DGE) (OR =0.58; 95% CI, 0.38-0.89; P=0.01) compared with internal stents. There were no significant differences in other postoperative outcomes between two stenting methods, including postoperative morbidity (OR =0.93; 95% CI, 0.39-2.23; P=0.88), overall mortality (OR =0.70; 95% CI, 0.22- 2.25; P=0.55), and intra-abdominal collections (OR =0.67; 95% CI, 0.26-1.71; P=0.40). Conclusions: Based upon this meta-analysis, the use of external pancreatic stents might have potential benefit in reducing the incidence of PF and DGE. Due to the limited number of original studies, more RCTs are needed to further support our result and clarify the issue.

Original languageEnglish (US)
Pages (from-to)397-407
Number of pages11
JournalChinese Journal of Cancer Research
Volume27
Issue number4
DOIs
StatePublished - Jan 1 2015

Keywords

  • Meta-analysis
  • Pancreatic duct stent
  • Pancreaticoduodenectomy (PD)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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