Comparison of patella lead with blood lead and tibia lead and their associations with neurobehavioral test scores

Carrie D. Dorsey, Byung Kook Lee, Karen I. Bolla, Virginia M. Weaver, Sung Soo Lee, Gap Soo Lee, Andrew C. Todd, Weiping Shi, Brian S. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Lead exposure in adults is associated with worse cognitive function in cross-sectional and longitudinal studies. Previous studies have mainly examined, relations with blood, lead or cortical bone lead; few have examined trabecular bone lead. Methods: We performed a cross-sectional analysis of the relations of patella, lead, and other lead biomarkers with measures of neurobehavioral and peripheral nervous system function in 652 lead, workers. Results: Patella lead was found to be associated, with worse performance on seven of 19 tests of manual dexterity, sensory vibration threshold, and depressive symptoms. The associations of patella lead, with cognitive function were essentially similar to those with blood, lead or tibia lead but of somewhat lower magnitude. Conclusions: In this study, measurement of patella lead did, not aid causal inference regarding cognitive effects when compared with blood lead and, tibia lead.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalJournal of occupational and environmental medicine
Volume48
Issue number5
DOIs
StatePublished - May 2006

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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