TY - JOUR
T1 - Comparison of oral penicillinase-resistant penicillins
T2 - Contrasts between agents and assays
AU - Bass, James W.
AU - Bruhn, Frederick W.
AU - Merritt, William T.
AU - Suttle, David E.
AU - Jirka, John H.
AU - Mesrobian, Robert B.
AU - Berkenbaugh, James T.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1982/4
Y1 - 1982/4
N2 - We observed the comparative serum levels and mean peak serum antistaphylococcal activity in eight fasting adults who received 500 mg each of dicloxacillin, cloxacillin, oxacillin, and nafcillin. Dicloxacillin achieved higher and more prolonged serum levels and greater peak serum antistaphylococcal titers than the other drugs studied. The higher degree of protein binding of dicloxacillin was reflected in a greater disparity between the peak antistaphylococcal activity observed when dilutions were done in serum compared to broth. The lesser protein-bound penicillins showed less disparity, but this effect was offset by the higher serum levels obtained by dicloxacillin. The higher protein binding of dicloxacillin did not prevent its having equal or superior antistaphylococcal activity in serum when the drugs were given in equal doses.
AB - We observed the comparative serum levels and mean peak serum antistaphylococcal activity in eight fasting adults who received 500 mg each of dicloxacillin, cloxacillin, oxacillin, and nafcillin. Dicloxacillin achieved higher and more prolonged serum levels and greater peak serum antistaphylococcal titers than the other drugs studied. The higher degree of protein binding of dicloxacillin was reflected in a greater disparity between the peak antistaphylococcal activity observed when dilutions were done in serum compared to broth. The lesser protein-bound penicillins showed less disparity, but this effect was offset by the higher serum levels obtained by dicloxacillin. The higher protein binding of dicloxacillin did not prevent its having equal or superior antistaphylococcal activity in serum when the drugs were given in equal doses.
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U2 - 10.1097/00007611-198204000-00008
DO - 10.1097/00007611-198204000-00008
M3 - Article
C2 - 7041278
AN - SCOPUS:0019924505
SN - 0038-4348
VL - 75
SP - 408
EP - 410
JO - Southern medical journal
JF - Southern medical journal
IS - 4
ER -