Comparison of MRI features of pathologically proven hepatocellular carcinoma between patients with hepatitis B and hepatitis C infection

Diane Dunst, Justin M. Ream, Victoria Khalef, Cristina H. Hajdu, Andrew B. Rosenkrantz

Research output: Contribution to journalArticle

Abstract

Purpose: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n. =. 18) or HCV (n. =. 33) patients; a third, more experienced, radiologist resolved discrepancies. Results: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P. =. .032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P = .073-0.088)]. Tumors were larger in HBV (P. ≤. .016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. Conclusion: Larger studies are required to confirm these preliminary findings.

Original languageEnglish (US)
Pages (from-to)352-356
Number of pages5
JournalClinical Imaging
Volume40
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • Hepatitis B
  • Hepatitis C
  • Hepatocellular carcinoma
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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