Comparison of MRI features of pathologically proven hepatocellular carcinoma between patients with hepatitis B and hepatitis C infection

Diane Dunst; Justin M. Ream; Victoria Khalef; Cristina H. Hajdu; Andrew B. Rosenkrantz

doi:10.1016/j.clinimag.2016.01.014

Comparison of MRI features of pathologically proven hepatocellular carcinoma between patients with hepatitis B and hepatitis C infection

Diane Dunst, Justin M. Ream, Victoria Khalef, Cristina H. Hajdu, Andrew B. Rosenkrantz

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n. =. 18) or HCV (n. =. 33) patients; a third, more experienced, radiologist resolved discrepancies. Results: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P. =. .032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P = .073-0.088)]. Tumors were larger in HBV (P. ≤. .016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. Conclusion: Larger studies are required to confirm these preliminary findings.

Original language	English (US)
Pages (from-to)	352-356
Number of pages	5
Journal	Clinical Imaging
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.clinimag.2016.01.014
State	Published - May 1 2016

Keywords

Hepatitis B
Hepatitis C
Hepatocellular carcinoma
MRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2016.01.014

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title = "Comparison of MRI features of pathologically proven hepatocellular carcinoma between patients with hepatitis B and hepatitis C infection",

abstract = "Purpose: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n. =. 18) or HCV (n. =. 33) patients; a third, more experienced, radiologist resolved discrepancies. Results: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P. =. .032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P = .073-0.088)]. Tumors were larger in HBV (P. ≤. .016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. Conclusion: Larger studies are required to confirm these preliminary findings.",

keywords = "Hepatitis B, Hepatitis C, Hepatocellular carcinoma, MRI",

author = "Diane Dunst and Ream, {Justin M.} and Victoria Khalef and Hajdu, {Cristina H.} and Rosenkrantz, {Andrew B.}",

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doi = "10.1016/j.clinimag.2016.01.014",

language = "English (US)",

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AU - Dunst, Diane

AU - Ream, Justin M.

AU - Khalef, Victoria

AU - Hajdu, Cristina H.

AU - Rosenkrantz, Andrew B.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Purpose: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n. =. 18) or HCV (n. =. 33) patients; a third, more experienced, radiologist resolved discrepancies. Results: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P. =. .032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P = .073-0.088)]. Tumors were larger in HBV (P. ≤. .016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. Conclusion: Larger studies are required to confirm these preliminary findings.

AB - Purpose: To compare MRI features of pathologically-proven hepatocellular carcinoma (HCC) between patients with hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: Two radiologists assessed 51 confirmed HCCs on MRI in HBV (n. =. 18) or HCV (n. =. 33) patients; a third, more experienced, radiologist resolved discrepancies. Results: Arterial hyperenhancement occurred more frequently in HCV (90.9% vs. 66.7%; P. =. .032), DWI/T2WI hyperintensity more frequently in HBV [(DWI: 78.6% vs. 45.8%, T2WI: 77.8% vs. 48.5%; P = .073-0.088)]. Tumors were larger in HBV (P. ≤. .016). Washout, pseudocapsule, homogeneity, circumscribed margins, lipid, iron, and visually low ADC were not different. Conclusion: Larger studies are required to confirm these preliminary findings.

KW - Hepatitis B

KW - Hepatitis C

KW - Hepatocellular carcinoma

KW - MRI

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Comparison of MRI features of pathologically proven hepatocellular carcinoma between patients with hepatitis B and hepatitis C infection

Abstract

Keywords

ASJC Scopus subject areas

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