Comparison of mortality risk for electrocardiographic abnormalities in men and women with and without coronary heart disease (from the Cardiovascular Health Study)

Pentti M. Rautaharju, Sijian Ge, Jennifer C. Nelson, Emily K. Marino Larsen, Bruce M. Psaty, Curt D. Furberg, Zhu Ming Zhang, John Robbins, John S. Gottdiener, Paulo H.M. Chaves

Research output: Contribution to journalArticle

Abstract

Mortality risk associated with electrocardiographic (ECG) abnormalities has been commonly reported to be lower in women than in men. We compared coronary heart disease (CHD) and all-cause mortality risk for ECG variables during a mean 9.1-year follow-up in 4,912 participants in the Cardiovascular Health Study who were <65 years of age. The hypothesis was that mortality risk for ECG abnormalities is not lower in women than in men. Five ECG variables were significant mortality predictors in Cox regression models that were adjusted for demographic, clinical, and medication variables. Gender differences were significant and mortality risk was higher in women for ECG estimates of left ventricular mass for both end points and for nondipolar QRS voltage for all-cause mortality. When evaluated simultaneously in multiple ECG variable risk models in subgroups that were stratified by baseline CHD status, no gender difference was significant. In the latter models, ST depression was a strong predictor of CHD mortality in groups with and without previous CHD. Other significant ECG predictors were previous myocardial infarction in the previous CHD group and nondipolar QRS voltage in the CHD-free group. Four ECG abnormalities were significant predictors of all-cause mortality in the CHD-free group, with risk increases of 18% to 50%. The risk of all-cause mortality in the previous CHD group was significantly increased for ST depression (by 64%), the ECG estimate of left ventricular mass (by 48%), and previous myocardial infarction (by 34%). In conclusion, we found no evidence that the relative risk of mortality for ECG abnormalities is lower in women than in men.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalAmerican Journal of Cardiology
Volume97
Issue number3
DOIs
StatePublished - Feb 1 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Rautaharju, P. M., Ge, S., Nelson, J. C., Marino Larsen, E. K., Psaty, B. M., Furberg, C. D., Zhang, Z. M., Robbins, J., Gottdiener, J. S., & Chaves, P. H. M. (2006). Comparison of mortality risk for electrocardiographic abnormalities in men and women with and without coronary heart disease (from the Cardiovascular Health Study). American Journal of Cardiology, 97(3), 309-315. https://doi.org/10.1016/j.amjcard.2005.08.046