@article{f620f347db6c4f758a881486c5b624dc,
title = "Comparison of male and female patients with amnestic mild cognitive impairment: Hippocampal hyperactivity and pattern separation memory performance",
abstract = "Introduction: Recent studies have suggested that sex confers a differential risk in the incidence and prevalence of Alzheimer's disease (AD) thought to be the result of the increased lifespan of women compared to men. However, other factors may contribute to risk beyond the effect of increased lifespan. Methods: This study examined the role of sex in hippocampal hyperactivity localized to the dentate gyrus (DG)/CA3 subregion of the hippocampus and associated episodic memory impairment, considered a characteristic feature of AD in patients with amnestic mild cognitive impairment (aMCI). Results: While participants with aMCI showed decreased memory performance and increased activation in the DG/CA3 when compared to controls, no significant sex-related differences in performance or activation were observed. Discussion: Although other factors may contribute to sex differences in the prevalence of AD these findings show that no sex differences are observed in hippocampal dysfunction characteristic of the aMCI phase of AD.",
keywords = "Alzheimer's disease, hippocampal hyperactivity, memory impairment, mild cognitive impairment, sex differences",
author = "Corona-Long, {Caitlin A.} and Tran, {Tammy T.} and Elizabeth Chang and Speck, {Caroline L.} and Michela Gallagher and Arnold Bakker",
note = "Funding Information: We would like to thank the staff of the F.M. Kirby Center for Functional Brain Imaging for their assistance with data collection. This work was supported by NIH grants RC2AG036419 and P50AG05146, and by an NIA T32 training grant and a National Defense Science and Engineering Graduate Fellowship (NDSEG) grant awarded by the DOD, Air Force Office of Scientific Research, National Defense Science and Engineering Graduate (NDSEG) Fellowship, 32 CFR 168a to T.T. Funding Information: We would like to thank the staff of the F.M. Kirby Center for Functional Brain Imaging for their assistance with data collection. This work was supported by NIH grants RC2AG036419 and P50AG05146, and by an NIA T32 training grant and a National Defense Science and Engineering Graduate Fellowship (NDSEG) grant awarded by the DOD, Air Force Office of Scientific Research, National Defense Science and Engineering Graduate (NDSEG) Fellowship, 32 CFR 168a to T.T. Michela Gallagher is the founder of AgeneBio. Michela Gallagher and Arnold Bakker are inventors on Johns Hopkins University intellectual property with patents pending and licensed to AgeneBio. Michela Gallagher consults for the company and owns company stock, which is subject to certain restrictions under university policy. Michela Gallagher and Arnold Bakker's role in the current study was in compliance with the conflict of interest policies of the Johns Hopkins School of Medicine. The other authors do not report any conflicts. Publisher Copyright: {\textcopyright} 2020 the Alzheimer's Association",
year = "2020",
doi = "10.1002/dad2.12043",
language = "English (US)",
volume = "12",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "1",
}